Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease

ABSTRACT In recent years, there has been a deluge of papers linking altered microbiome compositions to a myriad of diseases. Mechanistic insight into microbial drivers of disease phenotypes is essential for translation to novel therapies. A key mechanism by which microbes influence health is immune...

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Autor principal:	Catherine A. Lozupone
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	graft-versus-host disease T regulatory cell capsular polysaccharide gut microbiome host-microbiome interaction human immunodeficiency virus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f2b51db59fe14b2badaf28645174f375
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spelling	oai:doaj.org-article:f2b51db59fe14b2badaf28645174f3752021-12-02T18:44:38ZUnraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease10.1128/mSystems.00183-172379-5077https://doaj.org/article/f2b51db59fe14b2badaf28645174f3752018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00183-17https://doaj.org/toc/2379-5077ABSTRACT In recent years, there has been a deluge of papers linking altered microbiome compositions to a myriad of diseases. Mechanistic insight into microbial drivers of disease phenotypes is essential for translation to novel therapies. A key mechanism by which microbes influence health is immune modulation by components of their capsule and cell envelope and their metabolites. A major research focus of my laboratory is to gain mechanistic insight into which microbes modulate host immunity generally and in the context of disease. Using 16S rRNA-targeted sequencing, we have established associations between gut microbiome composition and immune-modulated disease phenotypes in diseases such as graft-versus-host disease in cancer patients undergoing stem cell transplantation. By integrating omics and computational approaches with laboratory experiments, we have expanded knowledge of mechanisms used by host-associated microbes to dampen inflammatory responses. This work has promise for development of novel microbiome-targeted therapeutics.Catherine A. LozuponeAmerican Society for Microbiologyarticlegraft-versus-host diseaseT regulatory cellcapsular polysaccharidegut microbiomehost-microbiome interactionhuman immunodeficiency virusMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	graft-versus-host disease T regulatory cell capsular polysaccharide gut microbiome host-microbiome interaction human immunodeficiency virus Microbiology QR1-502
spellingShingle	graft-versus-host disease T regulatory cell capsular polysaccharide gut microbiome host-microbiome interaction human immunodeficiency virus Microbiology QR1-502 Catherine A. Lozupone Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
description	ABSTRACT In recent years, there has been a deluge of papers linking altered microbiome compositions to a myriad of diseases. Mechanistic insight into microbial drivers of disease phenotypes is essential for translation to novel therapies. A key mechanism by which microbes influence health is immune modulation by components of their capsule and cell envelope and their metabolites. A major research focus of my laboratory is to gain mechanistic insight into which microbes modulate host immunity generally and in the context of disease. Using 16S rRNA-targeted sequencing, we have established associations between gut microbiome composition and immune-modulated disease phenotypes in diseases such as graft-versus-host disease in cancer patients undergoing stem cell transplantation. By integrating omics and computational approaches with laboratory experiments, we have expanded knowledge of mechanisms used by host-associated microbes to dampen inflammatory responses. This work has promise for development of novel microbiome-targeted therapeutics.
format	article
author	Catherine A. Lozupone
author_facet	Catherine A. Lozupone
author_sort	Catherine A. Lozupone
title	Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
title_short	Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
title_full	Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
title_fullStr	Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
title_full_unstemmed	Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease
title_sort	unraveling interactions between the microbiome and the host immune system to decipher mechanisms of disease
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/f2b51db59fe14b2badaf28645174f375
work_keys_str_mv	AT catherinealozupone unravelinginteractionsbetweenthemicrobiomeandthehostimmunesystemtodeciphermechanismsofdisease
_version_	1718377715728384000

Unraveling Interactions between the Microbiome and the Host Immune System To Decipher Mechanisms of Disease

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