The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants

Background: Platelets play an important role in the formation of pulmonary blood vessels, and thrombocytopenia is common in patients with pulmonary diseases. However, a few studies have reported on the role of platelets in bronchopulmonary dysplasia.Objective: The objective of the study was to explo...

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Autores principales:	Longli Yan, Zhuxiao Ren, Jianlan Wang, Xin Xia, Liling Yang, Jiayu Miao, Fang Xu, Weiwei Gao, Jie Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bronchopulmonary dysplasia platelet TPO megakaryocyte CD62P CD63 Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/f2bd362ed1af447fba6937a948387988
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spelling	oai:doaj.org-article:f2bd362ed1af447fba6937a9483879882021-11-30T18:32:23ZThe Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants2296-236010.3389/fped.2021.670469https://doaj.org/article/f2bd362ed1af447fba6937a9483879882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.670469/fullhttps://doaj.org/toc/2296-2360Background: Platelets play an important role in the formation of pulmonary blood vessels, and thrombocytopenia is common in patients with pulmonary diseases. However, a few studies have reported on the role of platelets in bronchopulmonary dysplasia.Objective: The objective of the study was to explore the relationship between platelet metabolism and bronchopulmonary dysplasia in premature infants.Methods: A prospective case-control study was performed in a cohort of premature infants (born with a gestational age <32 weeks and a birth weight <1,500 g) from June 1, 2017 to June 1, 2018. Subjects were stratified into two groups according to the diagnostic of bronchopulmonary dysplasia: with bronchopulmonary dysplasia (BPD group) and without bronchopulmonary dysplasia (control group). Platelet count, circulating megakaryocyte count (MK), platelet-activating markers (CD62P and CD63), and thrombopoietin (TPO) were recorded and compared in two groups 28 days after birth; then serial thrombopoietin levels and concomitant platelet counts were measured in infants with BPD.Results: A total of 252 premature infants were included in this study. Forty-eight premature infants developed BPD, 48 premature infants without BPD in the control group who were matched against the study infants for gestational age, birth weight, and admission diagnosis at the age of postnatal day 28. Compared with the controls, infants with BPD had significantly lower peripheral platelet count [BPD vs. controls: 180.3 (24.2) × 109/L vs. 345.6 (28.5) × 109/L, p = 0.001]. Circulating MK count in the BPD group was significantly more abundant than that in the control group [BPD vs. controls: 30.7 (4.5)/ml vs. 13.3 (2.6)/ml, p = 0.025]. The level of CD62p, CD63, and TPO in BPD group was significantly higher than the control group [29.7 (3.1%) vs. 14.5 (2.5%), 15.4 (2.0%) vs. 5.8 (1.7%), 301.4 (25.9) pg/ml vs. 120.4 (14.2) pg/ml, all p < 0.05]. Furthermore, the concentration of TPO was negatively correlated with platelet count in BPD group with thrombocytopenia.Conclusions: Our findings suggest that platelet metabolism is involved in the development of BPD in preterm infants. The possible mechanism might be through increased platelet activation and promoted TPO production by feedback.Longli YanZhuxiao RenJianlan WangXin XiaLiling YangJiayu MiaoFang XuWeiwei GaoJie YangFrontiers Media S.A.articlebronchopulmonary dysplasiaplateletTPOmegakaryocyteCD62PCD63PediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchopulmonary dysplasia platelet TPO megakaryocyte CD62P CD63 Pediatrics RJ1-570
spellingShingle	bronchopulmonary dysplasia platelet TPO megakaryocyte CD62P CD63 Pediatrics RJ1-570 Longli Yan Zhuxiao Ren Jianlan Wang Xin Xia Liling Yang Jiayu Miao Fang Xu Weiwei Gao Jie Yang The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
description	Background: Platelets play an important role in the formation of pulmonary blood vessels, and thrombocytopenia is common in patients with pulmonary diseases. However, a few studies have reported on the role of platelets in bronchopulmonary dysplasia.Objective: The objective of the study was to explore the relationship between platelet metabolism and bronchopulmonary dysplasia in premature infants.Methods: A prospective case-control study was performed in a cohort of premature infants (born with a gestational age <32 weeks and a birth weight <1,500 g) from June 1, 2017 to June 1, 2018. Subjects were stratified into two groups according to the diagnostic of bronchopulmonary dysplasia: with bronchopulmonary dysplasia (BPD group) and without bronchopulmonary dysplasia (control group). Platelet count, circulating megakaryocyte count (MK), platelet-activating markers (CD62P and CD63), and thrombopoietin (TPO) were recorded and compared in two groups 28 days after birth; then serial thrombopoietin levels and concomitant platelet counts were measured in infants with BPD.Results: A total of 252 premature infants were included in this study. Forty-eight premature infants developed BPD, 48 premature infants without BPD in the control group who were matched against the study infants for gestational age, birth weight, and admission diagnosis at the age of postnatal day 28. Compared with the controls, infants with BPD had significantly lower peripheral platelet count [BPD vs. controls: 180.3 (24.2) × 109/L vs. 345.6 (28.5) × 109/L, p = 0.001]. Circulating MK count in the BPD group was significantly more abundant than that in the control group [BPD vs. controls: 30.7 (4.5)/ml vs. 13.3 (2.6)/ml, p = 0.025]. The level of CD62p, CD63, and TPO in BPD group was significantly higher than the control group [29.7 (3.1%) vs. 14.5 (2.5%), 15.4 (2.0%) vs. 5.8 (1.7%), 301.4 (25.9) pg/ml vs. 120.4 (14.2) pg/ml, all p < 0.05]. Furthermore, the concentration of TPO was negatively correlated with platelet count in BPD group with thrombocytopenia.Conclusions: Our findings suggest that platelet metabolism is involved in the development of BPD in preterm infants. The possible mechanism might be through increased platelet activation and promoted TPO production by feedback.
format	article
author	Longli Yan Zhuxiao Ren Jianlan Wang Xin Xia Liling Yang Jiayu Miao Fang Xu Weiwei Gao Jie Yang
author_facet	Longli Yan Zhuxiao Ren Jianlan Wang Xin Xia Liling Yang Jiayu Miao Fang Xu Weiwei Gao Jie Yang
author_sort	Longli Yan
title	The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
title_short	The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
title_full	The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
title_fullStr	The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
title_full_unstemmed	The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants
title_sort	correlation between bronchopulmonary dysplasia and platelet metabolism in preterm infants
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f2bd362ed1af447fba6937a948387988
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The Correlation Between Bronchopulmonary Dysplasia and Platelet Metabolism in Preterm Infants

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