Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis

Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromat...

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Autores principales: Thierry Cheutin, Giacomo Cavalli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f7
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spelling oai:doaj.org-article:f2be048f34bc46d6ae518f8c7f16e3f72021-12-02T16:56:41ZLoss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis10.1038/s41467-018-05945-42041-1723https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f72018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05945-4https://doaj.org/toc/2041-1723Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromatin domains.Thierry CheutinGiacomo CavalliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thierry Cheutin
Giacomo Cavalli
Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
description Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromatin domains.
format article
author Thierry Cheutin
Giacomo Cavalli
author_facet Thierry Cheutin
Giacomo Cavalli
author_sort Thierry Cheutin
title Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_short Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_full Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_fullStr Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_full_unstemmed Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_sort loss of prc1 induces higher-order opening of hox loci independently of transcription during drosophila embryogenesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f7
work_keys_str_mv AT thierrycheutin lossofprc1induceshigherorderopeningofhoxlociindependentlyoftranscriptionduringdrosophilaembryogenesis
AT giacomocavalli lossofprc1induceshigherorderopeningofhoxlociindependentlyoftranscriptionduringdrosophilaembryogenesis
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