Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis

Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromat...

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Main Authors:	Thierry Cheutin, Giacomo Cavalli
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f7
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spelling	oai:doaj.org-article:f2be048f34bc46d6ae518f8c7f16e3f72021-12-02T16:56:41ZLoss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis10.1038/s41467-018-05945-42041-1723https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f72018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05945-4https://doaj.org/toc/2041-1723Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromatin domains.Thierry CheutinGiacomo CavalliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thierry Cheutin Giacomo Cavalli Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
description	Loss of Polycomb repressive complex 1 (PRC1) proteins usually results in both chromatin unfolding and ectopic transcription. Here, the authors analyze the temporal function of two PRC1 proteins during Drosophila embryogenesis and provide evidence that PRC1 maintains gene silencing by folding chromatin domains.
format	article
author	Thierry Cheutin Giacomo Cavalli
author_facet	Thierry Cheutin Giacomo Cavalli
author_sort	Thierry Cheutin
title	Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_short	Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_full	Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_fullStr	Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_full_unstemmed	Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis
title_sort	loss of prc1 induces higher-order opening of hox loci independently of transcription during drosophila embryogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f2be048f34bc46d6ae518f8c7f16e3f7
work_keys_str_mv	AT thierrycheutin lossofprc1induceshigherorderopeningofhoxlociindependentlyoftranscriptionduringdrosophilaembryogenesis AT giacomocavalli lossofprc1induceshigherorderopeningofhoxlociindependentlyoftranscriptionduringdrosophilaembryogenesis
_version_	1718382776042913792

Loss of PRC1 induces higher-order opening of Hox loci independently of transcription during Drosophila embryogenesis

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