The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK inhibitors in NB and combined ALK and PIM1 inhibitio...

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Autores principales: Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb
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spelling oai:doaj.org-article:f2be0a65707b41b5b2ef0367cf79b3cb2021-12-02T14:38:39ZThe targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status10.1038/s41467-019-13315-x2041-1723https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13315-xhttps://doaj.org/toc/2041-1723Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK inhibitors in NB and combined ALK and PIM1 inhibition enhances anti-tumour efficacy in vitro and in PDX models.Ricky M. TriggLiam C. LeeNina ProkophLeila JahangiriC. Patrick ReynoldsG. A. Amos BurkeNicola A. ProbstMiaojun HanJamie D. MatthewsHong Kai LimEleanor MannersSonia MartinezJoaquin PastorCarmen Blanco-AparicioOlaf MerkelInes Garces de los Fayos AlonsoPetra KodajovaSimone TangermannSandra HöglerJi LuoLukas KennerSuzanne D. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ricky M. Trigg
Liam C. Lee
Nina Prokoph
Leila Jahangiri
C. Patrick Reynolds
G. A. Amos Burke
Nicola A. Probst
Miaojun Han
Jamie D. Matthews
Hong Kai Lim
Eleanor Manners
Sonia Martinez
Joaquin Pastor
Carmen Blanco-Aparicio
Olaf Merkel
Ines Garces de los Fayos Alonso
Petra Kodajova
Simone Tangermann
Sandra Högler
Ji Luo
Lukas Kenner
Suzanne D. Turner
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
description Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK inhibitors in NB and combined ALK and PIM1 inhibition enhances anti-tumour efficacy in vitro and in PDX models.
format article
author Ricky M. Trigg
Liam C. Lee
Nina Prokoph
Leila Jahangiri
C. Patrick Reynolds
G. A. Amos Burke
Nicola A. Probst
Miaojun Han
Jamie D. Matthews
Hong Kai Lim
Eleanor Manners
Sonia Martinez
Joaquin Pastor
Carmen Blanco-Aparicio
Olaf Merkel
Ines Garces de los Fayos Alonso
Petra Kodajova
Simone Tangermann
Sandra Högler
Ji Luo
Lukas Kenner
Suzanne D. Turner
author_facet Ricky M. Trigg
Liam C. Lee
Nina Prokoph
Leila Jahangiri
C. Patrick Reynolds
G. A. Amos Burke
Nicola A. Probst
Miaojun Han
Jamie D. Matthews
Hong Kai Lim
Eleanor Manners
Sonia Martinez
Joaquin Pastor
Carmen Blanco-Aparicio
Olaf Merkel
Ines Garces de los Fayos Alonso
Petra Kodajova
Simone Tangermann
Sandra Högler
Ji Luo
Lukas Kenner
Suzanne D. Turner
author_sort Ricky M. Trigg
title The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
title_short The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
title_full The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
title_fullStr The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
title_full_unstemmed The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
title_sort targetable kinase pim1 drives alk inhibitor resistance in high-risk neuroblastoma independent of mycn status
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb
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