Dynamics of Matrix Metalloproteinases in Local Cold Injury

The relevance of cold injury is due to its high specific weight in the structure of injuries, complexities of complex therapy, and unsatisfactory results of treatment. It is known that in the pathogenesis of local cold injury, the leading role belongs to endothelial dysfunction, which secretes a hug...

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Autores principales:	M. I. Mikhailichenko, K. G. Shapovalov, V. A. Mudrov, O. S. Gruzdeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	local cold injury endothelial dysfunction matrix metalloproteinases Science Q
Acceso en línea:	https://doaj.org/article/f2bf5968d9b940bfbb820b332ec1c2d3
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id	oai:doaj.org-article:f2bf5968d9b940bfbb820b332ec1c2d3
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spelling	oai:doaj.org-article:f2bf5968d9b940bfbb820b332ec1c2d32021-11-23T06:14:43ZDynamics of Matrix Metalloproteinases in Local Cold Injury2541-94202587-959610.29413/ABS.2019-4.5.13https://doaj.org/article/f2bf5968d9b940bfbb820b332ec1c2d32019-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2174https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The relevance of cold injury is due to its high specific weight in the structure of injuries, complexities of complex therapy, and unsatisfactory results of treatment. It is known that in the pathogenesis of local cold injury, the leading role belongs to endothelial dysfunction, which secretes a huge amount of biologically active substances, including matrix metalloproteinases.Aim: to determine the dynamics of the content of matrix metalloproteinases of the second subfamily (MMP-2, MMP-9) in the serum of patients with local cold injury.Materials and methods. The study included 80 patients (60 men, 20 women) with frostbite of the III–IV degree of the foot to the level of the lower third of the leg in the late reactive period and the period of granulation and epithelization.Results. In the late reactive period in patients with cryopreservation, the level of MMP-2 was 3.4 times higher relative to the control (p = 0.011), on day 30 MMP-2 values did not differ from the control parameters (p = 0.103). The level of collagenase B (MMP-9) in patients with local cold injury on day 5 was 14.5 times higher than the control parameters (p = 0.002), on day 30 – 12.5 times higher compared to the control group (p = 0.000094).Conclusion. During the analysis of the data obtained, we can think about the dual nature of collagenases during the processes of inflammation. In a situation of distress, collagenases prevent endothelial dysfunction by eliminating the cellular structures of the endothelium to ensure adequate metabolism in tissues. Their importance as markers of failure of adequate flow of reparative processes is not excluded.M. I. MikhailichenkoK. G. ShapovalovV. A. MudrovO. S. GruzdevaScientific Сentre for Family Health and Human Reproduction Problemsarticlelocal cold injuryendothelial dysfunctionmatrix metalloproteinasesScienceQRUActa Biomedica Scientifica, Vol 4, Iss 5, Pp 79-83 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	local cold injury endothelial dysfunction matrix metalloproteinases Science Q
spellingShingle	local cold injury endothelial dysfunction matrix metalloproteinases Science Q M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva Dynamics of Matrix Metalloproteinases in Local Cold Injury
description	The relevance of cold injury is due to its high specific weight in the structure of injuries, complexities of complex therapy, and unsatisfactory results of treatment. It is known that in the pathogenesis of local cold injury, the leading role belongs to endothelial dysfunction, which secretes a huge amount of biologically active substances, including matrix metalloproteinases.Aim: to determine the dynamics of the content of matrix metalloproteinases of the second subfamily (MMP-2, MMP-9) in the serum of patients with local cold injury.Materials and methods. The study included 80 patients (60 men, 20 women) with frostbite of the III–IV degree of the foot to the level of the lower third of the leg in the late reactive period and the period of granulation and epithelization.Results. In the late reactive period in patients with cryopreservation, the level of MMP-2 was 3.4 times higher relative to the control (p = 0.011), on day 30 MMP-2 values did not differ from the control parameters (p = 0.103). The level of collagenase B (MMP-9) in patients with local cold injury on day 5 was 14.5 times higher than the control parameters (p = 0.002), on day 30 – 12.5 times higher compared to the control group (p = 0.000094).Conclusion. During the analysis of the data obtained, we can think about the dual nature of collagenases during the processes of inflammation. In a situation of distress, collagenases prevent endothelial dysfunction by eliminating the cellular structures of the endothelium to ensure adequate metabolism in tissues. Their importance as markers of failure of adequate flow of reparative processes is not excluded.
format	article
author	M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva
author_facet	M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva
author_sort	M. I. Mikhailichenko
title	Dynamics of Matrix Metalloproteinases in Local Cold Injury
title_short	Dynamics of Matrix Metalloproteinases in Local Cold Injury
title_full	Dynamics of Matrix Metalloproteinases in Local Cold Injury
title_fullStr	Dynamics of Matrix Metalloproteinases in Local Cold Injury
title_full_unstemmed	Dynamics of Matrix Metalloproteinases in Local Cold Injury
title_sort	dynamics of matrix metalloproteinases in local cold injury
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/f2bf5968d9b940bfbb820b332ec1c2d3
work_keys_str_mv	AT mimikhailichenko dynamicsofmatrixmetalloproteinasesinlocalcoldinjury AT kgshapovalov dynamicsofmatrixmetalloproteinasesinlocalcoldinjury AT vamudrov dynamicsofmatrixmetalloproteinasesinlocalcoldinjury AT osgruzdeva dynamicsofmatrixmetalloproteinasesinlocalcoldinjury
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Dynamics of Matrix Metalloproteinases in Local Cold Injury

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