Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain

Abstract Osteoarthritis (OA) pain is associated with peripheral and central sensitization in humans and results in widespread increased sensitivity across the body. Sensitization contributes to the OA-associated pain (OAP) state. We recently identified increased levels of an endogenous neurotrophic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ankita Gupta, Ludovica Chiavaccini, Laura M. Minnema, King Wa Chiu, David Knazovicky, Jonathan A. Hash, Santosh K. Mishra, B. Duncan X. Lascelles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2c1a83903b341769c4b67b2643fe7af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2c1a83903b341769c4b67b2643fe7af
record_format	dspace
spelling	oai:doaj.org-article:f2c1a83903b341769c4b67b2643fe7af2021-12-02T16:36:05ZSerum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain10.1038/s41598-021-85976-y2045-2322https://doaj.org/article/f2c1a83903b341769c4b67b2643fe7af2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85976-yhttps://doaj.org/toc/2045-2322Abstract Osteoarthritis (OA) pain is associated with peripheral and central sensitization in humans and results in widespread increased sensitivity across the body. Sensitization contributes to the OA-associated pain (OAP) state. We recently identified increased levels of an endogenous neurotrophic factor, artemin (ARTN), in dogs with OAP compared to healthy pain-free controls. Circulating ARTN released from damaged tissues in OA, may play a central role in widespread sensitivity and pain. However, the relationship between ARTN and somatosensory sensitivity remains unknown. The study aimed to assess the relationship between serum ARTN concentrations and measures of sensitivity in dogs with OAP using quantitative sensory testing. We hypothesized that there would be a positive association between circulating ARTN and increased sensitivity to mechanical and thermal stimuli in dogs with OAP. We used linear and logistic regression models to assess the relationship between ARTN, sensitization, and pain within a cohort of 43 dogs with spontaneous OAP. Serum ARTN was not associated with the degree of sensitization within dogs with OAP. Further, across dogs with varying OAP severity, we did not find any association between ARTN, and clinical measures of joint pain and disability. Although a relationship between ARTN and joint pain was not ruled out.Ankita GuptaLudovica ChiavacciniLaura M. MinnemaKing Wa ChiuDavid KnazovickyJonathan A. HashSantosh K. MishraB. Duncan X. LascellesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ankita Gupta Ludovica Chiavaccini Laura M. Minnema King Wa Chiu David Knazovicky Jonathan A. Hash Santosh K. Mishra B. Duncan X. Lascelles Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
description	Abstract Osteoarthritis (OA) pain is associated with peripheral and central sensitization in humans and results in widespread increased sensitivity across the body. Sensitization contributes to the OA-associated pain (OAP) state. We recently identified increased levels of an endogenous neurotrophic factor, artemin (ARTN), in dogs with OAP compared to healthy pain-free controls. Circulating ARTN released from damaged tissues in OA, may play a central role in widespread sensitivity and pain. However, the relationship between ARTN and somatosensory sensitivity remains unknown. The study aimed to assess the relationship between serum ARTN concentrations and measures of sensitivity in dogs with OAP using quantitative sensory testing. We hypothesized that there would be a positive association between circulating ARTN and increased sensitivity to mechanical and thermal stimuli in dogs with OAP. We used linear and logistic regression models to assess the relationship between ARTN, sensitization, and pain within a cohort of 43 dogs with spontaneous OAP. Serum ARTN was not associated with the degree of sensitization within dogs with OAP. Further, across dogs with varying OAP severity, we did not find any association between ARTN, and clinical measures of joint pain and disability. Although a relationship between ARTN and joint pain was not ruled out.
format	article
author	Ankita Gupta Ludovica Chiavaccini Laura M. Minnema King Wa Chiu David Knazovicky Jonathan A. Hash Santosh K. Mishra B. Duncan X. Lascelles
author_facet	Ankita Gupta Ludovica Chiavaccini Laura M. Minnema King Wa Chiu David Knazovicky Jonathan A. Hash Santosh K. Mishra B. Duncan X. Lascelles
author_sort	Ankita Gupta
title	Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
title_short	Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
title_full	Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
title_fullStr	Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
title_full_unstemmed	Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
title_sort	serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2c1a83903b341769c4b67b2643fe7af
work_keys_str_mv	AT ankitagupta serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT ludovicachiavaccini serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT lauramminnema serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT kingwachiu serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT davidknazovicky serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT jonathanahash serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT santoshkmishra serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain AT bduncanxlascelles serumarteminisnotcorrelatedwithsensitivitywithindogswithnaturallyoccurringosteoarthritispain
_version_	1718383669071052800

Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain

Ejemplares similares