A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine

Xuan Liu,* Ziying Yang,* Jiacheng Sun, Teng Ma, Fei Hua, Zhenya ShenDepartment of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workAbs...

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Autores principales:	Liu X, Yang Z, Sun J, Ma T, Hua F, Shen Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Mesenchymal stem cells Nanoparticles Toxic effects Imaging methods Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f2c44d262f694331a4ca7dbb866312d5
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spelling	oai:doaj.org-article:f2c44d262f694331a4ca7dbb866312d52021-12-02T02:23:50ZA brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine1178-2013https://doaj.org/article/f2c44d262f694331a4ca7dbb866312d52019-05-01T00:00:00Zhttps://www.dovepress.com/a-brief-review-of-cytotoxicity-of-nanoparticles-on-mesenchymal-stem-ce-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xuan Liu,* Ziying Yang,* Jiacheng Sun, Teng Ma, Fei Hua, Zhenya ShenDepartment of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workAbstract: Multipotent mesenchymal stem cells have shown great promise for application in regenerative medicine owing to their particular therapeutic effects, such as significant self-renewability, low immunogenicity, and ability to differentiate into a variety of specialized cells. However, there remain certain complicated and unavoidable problems that limit their further development and application. One of the challenges is to noninvasively monitor the delivery and biodistribution of transplanted stem cells during treatment without relying on behavioral endpoints or tissue histology, and it is important to explore the potential mechanisms to clarify how stem cells work in vivo. To solve these problems, various nanoparticles (NPs) and their corresponding imaging methods have been developed recently and have made great progress. In this review, we mainly discuss NPs used to label stem cells and their toxic effects on the latter, the imaging techniques to detect such NPs, and the current existing challenges in this field.Keywords: mesenchymal stem cells, nanoparticles, toxic effects, imaging methodsLiu XYang ZSun JMa THua FShen ZDove Medical PressarticleMesenchymal stem cellsNanoparticlesToxic effectsImaging methodsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3875-3892 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesenchymal stem cells Nanoparticles Toxic effects Imaging methods Medicine (General) R5-920
spellingShingle	Mesenchymal stem cells Nanoparticles Toxic effects Imaging methods Medicine (General) R5-920 Liu X Yang Z Sun J Ma T Hua F Shen Z A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
description	Xuan Liu,* Ziying Yang,* Jiacheng Sun, Teng Ma, Fei Hua, Zhenya ShenDepartment of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workAbstract: Multipotent mesenchymal stem cells have shown great promise for application in regenerative medicine owing to their particular therapeutic effects, such as significant self-renewability, low immunogenicity, and ability to differentiate into a variety of specialized cells. However, there remain certain complicated and unavoidable problems that limit their further development and application. One of the challenges is to noninvasively monitor the delivery and biodistribution of transplanted stem cells during treatment without relying on behavioral endpoints or tissue histology, and it is important to explore the potential mechanisms to clarify how stem cells work in vivo. To solve these problems, various nanoparticles (NPs) and their corresponding imaging methods have been developed recently and have made great progress. In this review, we mainly discuss NPs used to label stem cells and their toxic effects on the latter, the imaging techniques to detect such NPs, and the current existing challenges in this field.Keywords: mesenchymal stem cells, nanoparticles, toxic effects, imaging methods
format	article
author	Liu X Yang Z Sun J Ma T Hua F Shen Z
author_facet	Liu X Yang Z Sun J Ma T Hua F Shen Z
author_sort	Liu X
title	A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
title_short	A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
title_full	A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
title_fullStr	A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
title_full_unstemmed	A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
title_sort	brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f2c44d262f694331a4ca7dbb866312d5
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A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine

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