Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study

Abstract Aim To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and...

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Autores principales:	Rita S. Sitorus, Indra Maharddhika Pambudy, Rinawati Rohsiswatmo, Julie Dewi Barliana, Dian Estu Yulia, Indah Suci Widyahening
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Universal eye screening Hemorrhage Delivery Healthy newborn Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f2c89d8ffada4f6da52d6e62264ad740
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spelling	oai:doaj.org-article:f2c89d8ffada4f6da52d6e62264ad7402021-11-08T11:01:30ZRetinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study10.1186/s40942-021-00337-12056-9920https://doaj.org/article/f2c89d8ffada4f6da52d6e62264ad7402021-11-01T00:00:00Zhttps://doi.org/10.1186/s40942-021-00337-1https://doaj.org/toc/2056-9920Abstract Aim To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening.Rita S. SitorusIndra Maharddhika PambudyRinawati RohsiswatmoJulie Dewi BarlianaDian Estu YuliaIndah Suci WidyaheningBMCarticleUniversal eye screeningHemorrhageDeliveryHealthy newbornOphthalmologyRE1-994ENInternational Journal of Retina and Vitreous, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Universal eye screening Hemorrhage Delivery Healthy newborn Ophthalmology RE1-994
spellingShingle	Universal eye screening Hemorrhage Delivery Healthy newborn Ophthalmology RE1-994 Rita S. Sitorus Indra Maharddhika Pambudy Rinawati Rohsiswatmo Julie Dewi Barliana Dian Estu Yulia Indah Suci Widyahening Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
description	Abstract Aim To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening.
format	article
author	Rita S. Sitorus Indra Maharddhika Pambudy Rinawati Rohsiswatmo Julie Dewi Barliana Dian Estu Yulia Indah Suci Widyahening
author_facet	Rita S. Sitorus Indra Maharddhika Pambudy Rinawati Rohsiswatmo Julie Dewi Barliana Dian Estu Yulia Indah Suci Widyahening
author_sort	Rita S. Sitorus
title	Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
title_short	Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
title_full	Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
title_fullStr	Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
title_full_unstemmed	Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study
title_sort	retinal abnormalities in universal eye screening of healthy, full-term newborn infants in jakarta. the incidence and its risk factors: a pilot study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f2c89d8ffada4f6da52d6e62264ad740
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Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study

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