Hormonal type in the conditions of experimental multiple skeletal trauma

In experiment reproduced model of multiple skeletal trauma (fracture of bones of right forearm and lift shin) with stabilization of fragments with external fixation devices in 35 Chinchilla rabbits. All manipulations were realized, at general anesthesia. Standard treatment included anesthesia, antib...

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Autores principales:	M. L. Lebed, M. G. Kirpichenko, S. N. Bocharov, V. V. Gumanenko, L. V. Rodionova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	rabbits multiple skeletal trauma hormonal type adrenaline dexamethasone Science Q
Acceso en línea:	https://doaj.org/article/f2cae35b4a89410ebc29b5360f1c39f7
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spelling	oai:doaj.org-article:f2cae35b4a89410ebc29b5360f1c39f72021-11-23T06:14:26ZHormonal type in the conditions of experimental multiple skeletal trauma2541-94202587-9596https://doaj.org/article/f2cae35b4a89410ebc29b5360f1c39f72013-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1415https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In experiment reproduced model of multiple skeletal trauma (fracture of bones of right forearm and lift shin) with stabilization of fragments with external fixation devices in 35 Chinchilla rabbits. All manipulations were realized, at general anesthesia. Standard treatment included anesthesia, antibiotic prophyliaxis and. infusion therapy by common method. Decrease of metabolism activity was registered in the first group of laboratory animals at the standard treatment. That's why besided strandard treatment dexamethasone and adrenaline in average recommended doses was prescripted in the second group of rabbits in postoperative period for correction of posttraumatic hypobiosis. Laboratory control in several hours after the injection confirmed stable increase of level of corticosteroids in blood but it wasn't possible to register increase of concentration of adrenaline. Correlation analysis was realize to study the connection between the contentration of endogenous hormones in blood and. metabolism activity in rabbits in conditions of multiple skeletal trauma. At the consideration data as one array we determined high-significant (р < 0,001) direct moderate correlation between the values of rectal temperature and. the concentration of free thyroxine in blood (rs = 0,414), this connection was strong on the 3rd day after trauma (rs = 0,833; р < 0,001). Also indirect moderate correlation between values of rectal temperature and. the concentration of cortisol in blood of laboratory animals was registered (rs = 0,49; р < 0,001). The results of study of influence of adrenaline and. noradrenaline on the indices of metabolism activity weren't statistically significant. Obtained data allowed to make a conclusion about importance of endocrine activity of thyroid gland in the formation of adaptation strategy.M. L. LebedM. G. KirpichenkoS. N. BocharovV. V. GumanenkoL. V. RodionovaScientific Сentre for Family Health and Human Reproduction Problemsarticlerabbitsmultiple skeletal traumahormonal typeadrenalinedexamethasoneScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 111-114 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	rabbits multiple skeletal trauma hormonal type adrenaline dexamethasone Science Q
spellingShingle	rabbits multiple skeletal trauma hormonal type adrenaline dexamethasone Science Q M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko L. V. Rodionova Hormonal type in the conditions of experimental multiple skeletal trauma
description	In experiment reproduced model of multiple skeletal trauma (fracture of bones of right forearm and lift shin) with stabilization of fragments with external fixation devices in 35 Chinchilla rabbits. All manipulations were realized, at general anesthesia. Standard treatment included anesthesia, antibiotic prophyliaxis and. infusion therapy by common method. Decrease of metabolism activity was registered in the first group of laboratory animals at the standard treatment. That's why besided strandard treatment dexamethasone and adrenaline in average recommended doses was prescripted in the second group of rabbits in postoperative period for correction of posttraumatic hypobiosis. Laboratory control in several hours after the injection confirmed stable increase of level of corticosteroids in blood but it wasn't possible to register increase of concentration of adrenaline. Correlation analysis was realize to study the connection between the contentration of endogenous hormones in blood and. metabolism activity in rabbits in conditions of multiple skeletal trauma. At the consideration data as one array we determined high-significant (р < 0,001) direct moderate correlation between the values of rectal temperature and. the concentration of free thyroxine in blood (rs = 0,414), this connection was strong on the 3rd day after trauma (rs = 0,833; р < 0,001). Also indirect moderate correlation between values of rectal temperature and. the concentration of cortisol in blood of laboratory animals was registered (rs = 0,49; р < 0,001). The results of study of influence of adrenaline and. noradrenaline on the indices of metabolism activity weren't statistically significant. Obtained data allowed to make a conclusion about importance of endocrine activity of thyroid gland in the formation of adaptation strategy.
format	article
author	M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko L. V. Rodionova
author_facet	M. L. Lebed M. G. Kirpichenko S. N. Bocharov V. V. Gumanenko L. V. Rodionova
author_sort	M. L. Lebed
title	Hormonal type in the conditions of experimental multiple skeletal trauma
title_short	Hormonal type in the conditions of experimental multiple skeletal trauma
title_full	Hormonal type in the conditions of experimental multiple skeletal trauma
title_fullStr	Hormonal type in the conditions of experimental multiple skeletal trauma
title_full_unstemmed	Hormonal type in the conditions of experimental multiple skeletal trauma
title_sort	hormonal type in the conditions of experimental multiple skeletal trauma
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/f2cae35b4a89410ebc29b5360f1c39f7
work_keys_str_mv	AT mllebed hormonaltypeintheconditionsofexperimentalmultipleskeletaltrauma AT mgkirpichenko hormonaltypeintheconditionsofexperimentalmultipleskeletaltrauma AT snbocharov hormonaltypeintheconditionsofexperimentalmultipleskeletaltrauma AT vvgumanenko hormonaltypeintheconditionsofexperimentalmultipleskeletaltrauma AT lvrodionova hormonaltypeintheconditionsofexperimentalmultipleskeletaltrauma
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Hormonal type in the conditions of experimental multiple skeletal trauma

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