Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

Fawaz Y Azizieh,1 Khulood O Alyahya,2 Kamaludin Dingle1 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, International Centre for Applied Mathematics and Computational Bioengineering, West Mishref, Kuwait; 2Science Department, College of Basic Education, P...

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Autores principales:	Azizieh FY, Alyahya KO, Dingle K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Vitamin D Cytokines Adult women Self-reported symptoms Inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f2cc62900bf74e4487621d4293ae6723
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spelling	oai:doaj.org-article:f2cc62900bf74e4487621d4293ae67232021-12-02T01:29:31ZAssociation of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women1178-7031https://doaj.org/article/f2cc62900bf74e4487621d4293ae67232017-03-01T00:00:00Zhttps://www.dovepress.com/association-of-self-reported-symptoms-with-serum-levels-of-vitamin-d-a-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Fawaz Y Azizieh,1 Khulood O Alyahya,2 Kamaludin Dingle1 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, International Centre for Applied Mathematics and Computational Bioengineering, West Mishref, Kuwait; 2Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait Background: Although a large number of studies have investigated possible relationships among serum levels of vitamin D or cytokines with disease progress and prognosis, similar studies on self-reported symptoms are still controversial. The overall objective of this study was to look into the association between serum levels of vitamin D or cytokines with self-reported symptoms related to musculoskeletal pain, sleep disorders, and premenstrual syndrome (PMS) in healthy adult women.Subjects and methods: Venous blood samples were collected from 117 healthy adult women, and serum levels of vitamin D, pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Groups were tested for differences in single parameters, pro-:anti-inflammatory cytokine ratios, and differences in multivariate patterns.Results: There were no significant associations between serum levels of vitamin D and any of the self-reported symptoms studied. However, serum levels of certain pro-inflammatory cytokines were significantly higher in subjects with musculoskeletal pain (IL-8, P=0.008), sleep disorders (IFN-γ, P=0.02), and PMS (IL-8 and TNF-α, P=0.009 and 0.002, respectively) compared to subjects who reported no symptoms. The pro-:anti-inflammatory cytokine ratios showed pro-inflammatory cytokine dominance in subjects with self-reported symptoms, particularly in the groups with deficient levels of vitamin D. However, the multivariate cytokine-pattern analysis was significantly different between PMS groups only.Conclusion: These data point to a possible role of pro-inflammatory cytokines as a contributing factor in self-reported symptoms related to musculoskeletal pain, sleep disorders, and PMS. Keywords: vitamin D, cytokines, adult women, self-reported symptoms, inflammation  Azizieh FYAlyahya KODingle KDove Medical PressarticleVitamin DCytokinesAdult womenSelf-reported symptomsInflammationPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 10, Pp 19-28 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin D Cytokines Adult women Self-reported symptoms Inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Vitamin D Cytokines Adult women Self-reported symptoms Inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Azizieh FY Alyahya KO Dingle K Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
description	Fawaz Y Azizieh,1 Khulood O Alyahya,2 Kamaludin Dingle1 1Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, International Centre for Applied Mathematics and Computational Bioengineering, West Mishref, Kuwait; 2Science Department, College of Basic Education, Public Authority for Applied Education and Training, Kuwait City, Kuwait Background: Although a large number of studies have investigated possible relationships among serum levels of vitamin D or cytokines with disease progress and prognosis, similar studies on self-reported symptoms are still controversial. The overall objective of this study was to look into the association between serum levels of vitamin D or cytokines with self-reported symptoms related to musculoskeletal pain, sleep disorders, and premenstrual syndrome (PMS) in healthy adult women.Subjects and methods: Venous blood samples were collected from 117 healthy adult women, and serum levels of vitamin D, pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, IFN-γ, and TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were measured. Groups were tested for differences in single parameters, pro-:anti-inflammatory cytokine ratios, and differences in multivariate patterns.Results: There were no significant associations between serum levels of vitamin D and any of the self-reported symptoms studied. However, serum levels of certain pro-inflammatory cytokines were significantly higher in subjects with musculoskeletal pain (IL-8, P=0.008), sleep disorders (IFN-γ, P=0.02), and PMS (IL-8 and TNF-α, P=0.009 and 0.002, respectively) compared to subjects who reported no symptoms. The pro-:anti-inflammatory cytokine ratios showed pro-inflammatory cytokine dominance in subjects with self-reported symptoms, particularly in the groups with deficient levels of vitamin D. However, the multivariate cytokine-pattern analysis was significantly different between PMS groups only.Conclusion: These data point to a possible role of pro-inflammatory cytokines as a contributing factor in self-reported symptoms related to musculoskeletal pain, sleep disorders, and PMS. Keywords: vitamin D, cytokines, adult women, self-reported symptoms, inflammation
format	article
author	Azizieh FY Alyahya KO Dingle K
author_facet	Azizieh FY Alyahya KO Dingle K
author_sort	Azizieh FY
title	Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
title_short	Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
title_full	Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
title_fullStr	Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
title_full_unstemmed	Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women
title_sort	association of self-reported symptoms with serum levels of vitamin d and multivariate cytokine profile in healthy women
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f2cc62900bf74e4487621d4293ae6723
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Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women

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