Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study

Abstract Background Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein that plays an important role in nucleotide excision repair and can reduce oxidative stress, which may be involved in the development of preeclampsia (PE). Therefore, the aim of this study was...

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Autores principales:	Jingli Wang, Chengcheng Guan, Jing Sui, Yucui Zang, Yuwen Wu, Ru Zhang, Xiaoying Qi, Shunfu Piao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chinese Han Shandong province DNA repair XPC Polymorphism Preeclampsia Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/f2cd2305238a488cb513c2f492c6d022
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spelling	oai:doaj.org-article:f2cd2305238a488cb513c2f492c6d0222021-11-28T12:29:45ZAssociation between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study10.1186/s12884-021-04242-11471-2393https://doaj.org/article/f2cd2305238a488cb513c2f492c6d0222021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04242-1https://doaj.org/toc/1471-2393Abstract Background Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein that plays an important role in nucleotide excision repair and can reduce oxidative stress, which may be involved in the development of preeclampsia (PE). Therefore, the aim of this study was to explore whether XPC polymorphisms were relevant to the genetic susceptibility to PE in Chinese Han women. Method A total of 1276 healthy pregnant women were included as the control group and 958 pregnant women with PE as the case group. DNA was extracted from peripheral blood samples to perform genotyping of loci rs2228001 and rs2228000 in XPC through real-time quantitative polymerase chain reaction (PCR). The relationship between XPC and susceptibility to PE was evaluated by comparing the genotypic and allelic frequencies between the two groups of pregnant women. Results Polymorphism of rs2228000 may be associated with PE risk and allele T may play a protective role (genotype, χ2 = 38.961, P < 0.001 and allele χ2 = 21.746 P < 0.001, odds ratio (OR) = 0.885, 95% confidence interval (CI) = 0.840-0.932). No significant difference was found between the two groups in rs2228001,(genotype χ2 = 3.148, P = 0.207 and allele χ2 = 0.59, P = 0.442, OR = 1.017, 95% CI = 0.974–1.062). When the frequencies of genotypes and alleles for early- and late-onset PE, mild PE and severe PE were compared with those of controls, the results were consistent with the large clinical sample. Conclusion Our data suggest that the genetic variant rs2228000 in XPC may be associated with PE risk in Chinese Han women, and that pregnant women with the TT genotype have a reduced risk of PE. Further investigations are needed to confirm these findings in other regions or larger prospective populations.Jingli WangChengcheng GuanJing SuiYucui ZangYuwen WuRu ZhangXiaoying QiShunfu PiaoBMCarticleChinese HanShandong provinceDNA repairXPCPolymorphismPreeclampsiaGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chinese Han Shandong province DNA repair XPC Polymorphism Preeclampsia Gynecology and obstetrics RG1-991
spellingShingle	Chinese Han Shandong province DNA repair XPC Polymorphism Preeclampsia Gynecology and obstetrics RG1-991 Jingli Wang Chengcheng Guan Jing Sui Yucui Zang Yuwen Wu Ru Zhang Xiaoying Qi Shunfu Piao Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
description	Abstract Background Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein that plays an important role in nucleotide excision repair and can reduce oxidative stress, which may be involved in the development of preeclampsia (PE). Therefore, the aim of this study was to explore whether XPC polymorphisms were relevant to the genetic susceptibility to PE in Chinese Han women. Method A total of 1276 healthy pregnant women were included as the control group and 958 pregnant women with PE as the case group. DNA was extracted from peripheral blood samples to perform genotyping of loci rs2228001 and rs2228000 in XPC through real-time quantitative polymerase chain reaction (PCR). The relationship between XPC and susceptibility to PE was evaluated by comparing the genotypic and allelic frequencies between the two groups of pregnant women. Results Polymorphism of rs2228000 may be associated with PE risk and allele T may play a protective role (genotype, χ2 = 38.961, P < 0.001 and allele χ2 = 21.746 P < 0.001, odds ratio (OR) = 0.885, 95% confidence interval (CI) = 0.840-0.932). No significant difference was found between the two groups in rs2228001,(genotype χ2 = 3.148, P = 0.207 and allele χ2 = 0.59, P = 0.442, OR = 1.017, 95% CI = 0.974–1.062). When the frequencies of genotypes and alleles for early- and late-onset PE, mild PE and severe PE were compared with those of controls, the results were consistent with the large clinical sample. Conclusion Our data suggest that the genetic variant rs2228000 in XPC may be associated with PE risk in Chinese Han women, and that pregnant women with the TT genotype have a reduced risk of PE. Further investigations are needed to confirm these findings in other regions or larger prospective populations.
format	article
author	Jingli Wang Chengcheng Guan Jing Sui Yucui Zang Yuwen Wu Ru Zhang Xiaoying Qi Shunfu Piao
author_facet	Jingli Wang Chengcheng Guan Jing Sui Yucui Zang Yuwen Wu Ru Zhang Xiaoying Qi Shunfu Piao
author_sort	Jingli Wang
title	Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
title_short	Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
title_full	Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
title_fullStr	Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
title_full_unstemmed	Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study
title_sort	association between polymorphisms rs2228001 and rs2228000 in xpc and genetic susceptibility to preeclampsia: a case control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f2cd2305238a488cb513c2f492c6d022
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Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study

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