Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles

The elusiveness encircling around the domain of cognition, its impairment, and the poor prognosis of Alzheimer’s disease has made early diagnosis a necessity. The noticeable symptoms in these conditions appear years later after the neuropathological changes occur in the brain. Exosomes, a small-size...

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Autores principales:	Simran Rastogi, Komal Rani, Saroj Kumar
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f2d070e710234886a29b9cb1c74c04fa
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spelling	oai:doaj.org-article:f2d070e710234886a29b9cb1c74c04fa2021-11-30T23:35:46ZProgression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles2633-105510.1177/26331055211058687https://doaj.org/article/f2d070e710234886a29b9cb1c74c04fa2021-11-01T00:00:00Zhttps://doi.org/10.1177/26331055211058687https://doaj.org/toc/2633-1055The elusiveness encircling around the domain of cognition, its impairment, and the poor prognosis of Alzheimer’s disease has made early diagnosis a necessity. The noticeable symptoms in these conditions appear years later after the neuropathological changes occur in the brain. Exosomes, a small-sized extracellular vesicle facilitate intercellular communication of disease pathologies and their cargo can provide molecular information about its place of origin. The study titled “A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer’s disease” was an attempt toward understanding the role of salivary small-sized extracellular vesicular (EV’s) cargo in monitoring the progression. Outcomes of the study represent, that the salivary small-sized EV’s (ssEV’s) levels were higher in the cognitively impaired and Alzheimer’s diseased as well the differential expression of the protein in the cargo correlates well with the disease severity staging. Thus, it can help in the development of an early non-invasive screening method.Simran RastogiKomal RaniSaroj KumarSAGE PublishingarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroscience Insights, Vol 16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Simran Rastogi Komal Rani Saroj Kumar Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
description	The elusiveness encircling around the domain of cognition, its impairment, and the poor prognosis of Alzheimer’s disease has made early diagnosis a necessity. The noticeable symptoms in these conditions appear years later after the neuropathological changes occur in the brain. Exosomes, a small-sized extracellular vesicle facilitate intercellular communication of disease pathologies and their cargo can provide molecular information about its place of origin. The study titled “A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer’s disease” was an attempt toward understanding the role of salivary small-sized extracellular vesicular (EV’s) cargo in monitoring the progression. Outcomes of the study represent, that the salivary small-sized EV’s (ssEV’s) levels were higher in the cognitively impaired and Alzheimer’s diseased as well the differential expression of the protein in the cargo correlates well with the disease severity staging. Thus, it can help in the development of an early non-invasive screening method.
format	article
author	Simran Rastogi Komal Rani Saroj Kumar
author_facet	Simran Rastogi Komal Rani Saroj Kumar
author_sort	Simran Rastogi
title	Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
title_short	Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
title_full	Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
title_fullStr	Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
title_full_unstemmed	Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles
title_sort	progression of cognitive impairment to alzheimer’s disease: through the lens of salivary extracellular vesicles
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/f2d070e710234886a29b9cb1c74c04fa
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Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles

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