Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis

Objective We conducted meta-analysis of relevant case-control trials to determine the association between endothelial nitric oxide synthase (eNOS) intron 4a/b gene polymorphisms and hypertension susceptibility. Methods We searched the PubMed, Cochrane, and Embase databases using relevant keywords an...

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Autores principales:	Xiru Xu, Woruo Ye, Hanqing Chen, Ming Liu, Weimin Jiang, Zhuyuan Fang
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f2d655faa03042b9b4aaee917b77b399
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spelling	oai:doaj.org-article:f2d655faa03042b9b4aaee917b77b3992021-12-02T08:04:58ZAssociation of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis1473-230010.1177/0300060520979230https://doaj.org/article/f2d655faa03042b9b4aaee917b77b3992021-11-01T00:00:00Zhttps://doi.org/10.1177/0300060520979230https://doaj.org/toc/1473-2300Objective We conducted meta-analysis of relevant case-control trials to determine the association between endothelial nitric oxide synthase (eNOS) intron 4a/b gene polymorphisms and hypertension susceptibility. Methods We searched the PubMed, Cochrane, and Embase databases using relevant keywords and reviewed pertinent literature sources. All articles published up to July 2019 were considered for inclusion. Based on the qualified studies, we performed a meta-analysis of the associations between eNOS intron 4a/b polymorphisms and the risk of hypertension. Results Fourteen studies were included in this meta-analysis, including 3344 cases and 3377 controls. The eNOS intron 4a/b locus was significantly associated with increased susceptibility to hypertension (including essential hypertension) in the overall population, according to dominant, allelic, homozygote, heterozygote, and regressive models, in the mixed population according to the regressive model, and in Caucasians according to the dominant, allelic, heterozygote, and regressive models. The eNOS intron 4a/b locus was also significantly associated with increased susceptibility to essential hypertension in the mixed population according to the heterozygote model. Conclusion eNOS intron 4a/b gene polymorphisms increase susceptibility to hypertension, including essential hypertension.Xiru XuWoruo YeHanqing ChenMing LiuWeimin JiangZhuyuan FangSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiru Xu Woruo Ye Hanqing Chen Ming Liu Weimin Jiang Zhuyuan Fang Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
description	Objective We conducted meta-analysis of relevant case-control trials to determine the association between endothelial nitric oxide synthase (eNOS) intron 4a/b gene polymorphisms and hypertension susceptibility. Methods We searched the PubMed, Cochrane, and Embase databases using relevant keywords and reviewed pertinent literature sources. All articles published up to July 2019 were considered for inclusion. Based on the qualified studies, we performed a meta-analysis of the associations between eNOS intron 4a/b polymorphisms and the risk of hypertension. Results Fourteen studies were included in this meta-analysis, including 3344 cases and 3377 controls. The eNOS intron 4a/b locus was significantly associated with increased susceptibility to hypertension (including essential hypertension) in the overall population, according to dominant, allelic, homozygote, heterozygote, and regressive models, in the mixed population according to the regressive model, and in Caucasians according to the dominant, allelic, heterozygote, and regressive models. The eNOS intron 4a/b locus was also significantly associated with increased susceptibility to essential hypertension in the mixed population according to the heterozygote model. Conclusion eNOS intron 4a/b gene polymorphisms increase susceptibility to hypertension, including essential hypertension.
format	article
author	Xiru Xu Woruo Ye Hanqing Chen Ming Liu Weimin Jiang Zhuyuan Fang
author_facet	Xiru Xu Woruo Ye Hanqing Chen Ming Liu Weimin Jiang Zhuyuan Fang
author_sort	Xiru Xu
title	Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
title_short	Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
title_full	Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
title_fullStr	Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
title_full_unstemmed	Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
title_sort	association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/f2d655faa03042b9b4aaee917b77b399
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Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis

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