α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability

α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability

Abstract Pathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one o...

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Main Authors: Abeer Dagra, Douglas R. Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A. Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R. Alonge, Joseph J. Lebowitz, Brittany Ulm, Mengfei Bu, Carissa A. Hansen, Nikhil Urs, Benoit I. Giasson, Habibeh Khoshbouei
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Neurology. Diseases of the nervous system
RC346-429
Online Access:https://doaj.org/article/f2d73277ffa44878aef6f4a90d2e0da9
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