MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2.

MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2.

<h4>Background</h4>Amylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes. Plasma amylin levels are elevated in individuals with obesity and insulin resistance. Monocyte chemoattractant protein-1 (MCP-1, CCL2) is involved in insulin resist...

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Autores principales: Kun Cai, Dongfei Qi, Xinwei Hou, Oumei Wang, Juan Chen, Bo Deng, Lihua Qian, Xiaolong Liu, Yingying Le
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/f2d75063f2704988984e0f98dfcbdb7d
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