Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma

Abstract Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and simi...

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Autores principales:	Nina P. Connolly, Amol C. Shetty, Jesse A. Stokum, Ina Hoeschele, Marni B. Siegel, C. Ryan Miller, Anthony J. Kim, Cheng-Ying Ho, Eduardo Davila, J. Marc Simard, Scott E. Devine, John H. Rossmeisl, Eric C. Holland, Jeffrey A. Winkles, Graeme F. Woodworth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2d89c7796d7442691323a555b449266
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spelling	oai:doaj.org-article:f2d89c7796d7442691323a555b4492662021-12-02T15:08:01ZCross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma10.1038/s41598-018-19451-62045-2322https://doaj.org/article/f2d89c7796d7442691323a555b4492662018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19451-6https://doaj.org/toc/2045-2322Abstract Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and similarities in glioma biology as conveyed by transcriptomic patterns across four mammalian hosts: rats, mice, dogs, and humans. Given the inherent intra-tumoral molecular heterogeneity of human glioma, we focused this study on tumors with upregulation of the platelet-derived growth factor signaling axis, a common and early alteration in human gliomagenesis. The results reveal core neoplastic alterations in mammalian glioma, as well as unique contributions of the tumor host to neoplastic processes. Notable differences were observed in gene expression patterns as well as related biological pathways and cell populations known to mediate key elements of glioma biology, including angiogenesis, immune evasion, and brain invasion. These data provide new insights regarding mammalian models of human glioma, and how these insights and models relate to our current understanding of the human disease.Nina P. ConnollyAmol C. ShettyJesse A. StokumIna HoescheleMarni B. SiegelC. Ryan MillerAnthony J. KimCheng-Ying HoEduardo DavilaJ. Marc SimardScott E. DevineJohn H. RossmeislEric C. HollandJeffrey A. WinklesGraeme F. WoodworthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nina P. Connolly Amol C. Shetty Jesse A. Stokum Ina Hoeschele Marni B. Siegel C. Ryan Miller Anthony J. Kim Cheng-Ying Ho Eduardo Davila J. Marc Simard Scott E. Devine John H. Rossmeisl Eric C. Holland Jeffrey A. Winkles Graeme F. Woodworth Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
description	Abstract Glioma is a unique neoplastic disease that develops exclusively in the central nervous system (CNS) and rarely metastasizes to other tissues. This feature strongly implicates the tumor-host CNS microenvironment in gliomagenesis and tumor progression. We investigated the differences and similarities in glioma biology as conveyed by transcriptomic patterns across four mammalian hosts: rats, mice, dogs, and humans. Given the inherent intra-tumoral molecular heterogeneity of human glioma, we focused this study on tumors with upregulation of the platelet-derived growth factor signaling axis, a common and early alteration in human gliomagenesis. The results reveal core neoplastic alterations in mammalian glioma, as well as unique contributions of the tumor host to neoplastic processes. Notable differences were observed in gene expression patterns as well as related biological pathways and cell populations known to mediate key elements of glioma biology, including angiogenesis, immune evasion, and brain invasion. These data provide new insights regarding mammalian models of human glioma, and how these insights and models relate to our current understanding of the human disease.
format	article
author	Nina P. Connolly Amol C. Shetty Jesse A. Stokum Ina Hoeschele Marni B. Siegel C. Ryan Miller Anthony J. Kim Cheng-Ying Ho Eduardo Davila J. Marc Simard Scott E. Devine John H. Rossmeisl Eric C. Holland Jeffrey A. Winkles Graeme F. Woodworth
author_facet	Nina P. Connolly Amol C. Shetty Jesse A. Stokum Ina Hoeschele Marni B. Siegel C. Ryan Miller Anthony J. Kim Cheng-Ying Ho Eduardo Davila J. Marc Simard Scott E. Devine John H. Rossmeisl Eric C. Holland Jeffrey A. Winkles Graeme F. Woodworth
author_sort	Nina P. Connolly
title	Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
title_short	Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
title_full	Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
title_fullStr	Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
title_full_unstemmed	Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
title_sort	cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f2d89c7796d7442691323a555b449266
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Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma

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