Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor

2-deoxy-<i>D</i>-Ribose (2dDR) was first identified in 1930 in the structure of DNA and discovered as a degradation product of it later when the enzyme thymidine phosphorylase breaks down thymidine into thymine. In 2017, our research group explored the development of wound dressings base...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Serkan Dikici, Muhammad Yar, Anthony J. Bullock, Joanna Shepherd, Sabiniano Roman, Sheila MacNeil
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	2-deoxy-<i>D</i>-Ribose (2dDR) deoxy sugar angiogenesis wound healing chronic wounds wound dressing Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f2da64020fa24606898dc0f3d4c42d83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2da64020fa24606898dc0f3d4c42d83
record_format	dspace
spelling	oai:doaj.org-article:f2da64020fa24606898dc0f3d4c42d832021-11-11T16:54:13ZDeveloping Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor10.3390/ijms2221114371422-00671661-6596https://doaj.org/article/f2da64020fa24606898dc0f3d4c42d832021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11437https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-00672-deoxy-<i>D</i>-Ribose (2dDR) was first identified in 1930 in the structure of DNA and discovered as a degradation product of it later when the enzyme thymidine phosphorylase breaks down thymidine into thymine. In 2017, our research group explored the development of wound dressings based on the delivery of this sugar to induce angiogenesis in chronic wounds. In this review, we will survey the small volume of conflicting literature on this and related sugars, some of which are reported to be anti-angiogenic. We review the evidence of 2dDR having the ability to stimulate a range of pro-angiogenic activities in vitro and in a chick pro-angiogenic bioassay and to stimulate new blood vessel formation and wound healing in normal and diabetic rat models. The biological actions of 2dDR were found to be 80 to 100% as effective as VEGF in addition to upregulating the production of VEGF. We then demonstrated the uptake and delivery of the sugar from a range of experimental and commercial dressings. In conclusion, its pro-angiogenic properties combined with its improved stability on storage compared to VEGF, its low cost, and ease of incorporation into a range of established wound dressings make 2dDR an attractive alternative to VEGF for wound dressing development.Serkan DikiciMuhammad YarAnthony J. BullockJoanna ShepherdSabiniano RomanSheila MacNeilMDPI AGarticle2-deoxy-<i>D</i>-Ribose (2dDR)deoxy sugarangiogenesiswound healingchronic woundswound dressingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11437, p 11437 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	2-deoxy-<i>D</i>-Ribose (2dDR) deoxy sugar angiogenesis wound healing chronic wounds wound dressing Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	2-deoxy-<i>D</i>-Ribose (2dDR) deoxy sugar angiogenesis wound healing chronic wounds wound dressing Biology (General) QH301-705.5 Chemistry QD1-999 Serkan Dikici Muhammad Yar Anthony J. Bullock Joanna Shepherd Sabiniano Roman Sheila MacNeil Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
description	2-deoxy-<i>D</i>-Ribose (2dDR) was first identified in 1930 in the structure of DNA and discovered as a degradation product of it later when the enzyme thymidine phosphorylase breaks down thymidine into thymine. In 2017, our research group explored the development of wound dressings based on the delivery of this sugar to induce angiogenesis in chronic wounds. In this review, we will survey the small volume of conflicting literature on this and related sugars, some of which are reported to be anti-angiogenic. We review the evidence of 2dDR having the ability to stimulate a range of pro-angiogenic activities in vitro and in a chick pro-angiogenic bioassay and to stimulate new blood vessel formation and wound healing in normal and diabetic rat models. The biological actions of 2dDR were found to be 80 to 100% as effective as VEGF in addition to upregulating the production of VEGF. We then demonstrated the uptake and delivery of the sugar from a range of experimental and commercial dressings. In conclusion, its pro-angiogenic properties combined with its improved stability on storage compared to VEGF, its low cost, and ease of incorporation into a range of established wound dressings make 2dDR an attractive alternative to VEGF for wound dressing development.
format	article
author	Serkan Dikici Muhammad Yar Anthony J. Bullock Joanna Shepherd Sabiniano Roman Sheila MacNeil
author_facet	Serkan Dikici Muhammad Yar Anthony J. Bullock Joanna Shepherd Sabiniano Roman Sheila MacNeil
author_sort	Serkan Dikici
title	Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
title_short	Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
title_full	Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
title_fullStr	Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
title_full_unstemmed	Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
title_sort	developing wound dressings using 2-deoxy-<i>d</i>-ribose to induce angiogenesis as a backdoor route for stimulating the production of vascular endothelial growth factor
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2da64020fa24606898dc0f3d4c42d83
work_keys_str_mv	AT serkandikici developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor AT muhammadyar developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor AT anthonyjbullock developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor AT joannashepherd developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor AT sabinianoroman developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor AT sheilamacneil developingwounddressingsusing2deoxyidiribosetoinduceangiogenesisasabackdoorrouteforstimulatingtheproductionofvascularendothelialgrowthfactor
_version_	1718432213140242432

Developing Wound Dressings Using 2-deoxy-<i>D</i>-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor

Ejemplares similares