A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes

Abstract The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR...

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Autores principales:	Fabiana dos Santos Carolino Firmo Pereira, Raphael Mendonça Guimarães, Alexandre Ramos Lucidi, Doralina Guimarães Brum, Carmen Lucia Antão Paiva, Regina Maria Papais Alvarenga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2dabe7b525944e381448668a1d8f996
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spelling	oai:doaj.org-article:f2dabe7b525944e381448668a1d8f9962021-12-02T15:08:19ZA systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes10.1038/s41598-019-45081-72045-2322https://doaj.org/article/f2dabe7b525944e381448668a1d8f9962019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45081-7https://doaj.org/toc/2045-2322Abstract The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer’s disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer’s disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices.Fabiana dos Santos Carolino Firmo PereiraRaphael Mendonça GuimarãesAlexandre Ramos LucidiDoralina Guimarães BrumCarmen Lucia Antão PaivaRegina Maria Papais AlvarengaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabiana dos Santos Carolino Firmo Pereira Raphael Mendonça Guimarães Alexandre Ramos Lucidi Doralina Guimarães Brum Carmen Lucia Antão Paiva Regina Maria Papais Alvarenga A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
description	Abstract The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer’s disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer’s disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices.
format	article
author	Fabiana dos Santos Carolino Firmo Pereira Raphael Mendonça Guimarães Alexandre Ramos Lucidi Doralina Guimarães Brum Carmen Lucia Antão Paiva Regina Maria Papais Alvarenga
author_facet	Fabiana dos Santos Carolino Firmo Pereira Raphael Mendonça Guimarães Alexandre Ramos Lucidi Doralina Guimarães Brum Carmen Lucia Antão Paiva Regina Maria Papais Alvarenga
author_sort	Fabiana dos Santos Carolino Firmo Pereira
title	A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
title_short	A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
title_full	A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
title_fullStr	A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
title_full_unstemmed	A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes
title_sort	systematic literature review on the european, african and amerindian genetic ancestry components on brazilian health outcomes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f2dabe7b525944e381448668a1d8f996
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A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes

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