Holding multiple items in short term memory: a neural mechanism.

Human short term memory has a capacity of several items maintained simultaneously. We show how the number of short term memory representations that an attractor network modeling a cortical local network can simultaneously maintain active is increased by using synaptic facilitation of the type found...

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Autores principales:	Edmund T Rolls, Laura Dempere-Marco, Gustavo Deco
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2df580f2aab4ab0886dfbd98a52ff3c
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id	oai:doaj.org-article:f2df580f2aab4ab0886dfbd98a52ff3c
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spelling	oai:doaj.org-article:f2df580f2aab4ab0886dfbd98a52ff3c2021-11-18T07:49:22ZHolding multiple items in short term memory: a neural mechanism.1932-620310.1371/journal.pone.0061078https://doaj.org/article/f2df580f2aab4ab0886dfbd98a52ff3c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613789/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Human short term memory has a capacity of several items maintained simultaneously. We show how the number of short term memory representations that an attractor network modeling a cortical local network can simultaneously maintain active is increased by using synaptic facilitation of the type found in the prefrontal cortex. We have been able to maintain 9 short term memories active simultaneously in integrate-and-fire simulations where the proportion of neurons in each population, the sparseness, is 0.1, and have confirmed the stability of such a system with mean field analyses. Without synaptic facilitation the system can maintain many fewer memories active in the same network. The system operates because of the effectively increased synaptic strengths formed by the synaptic facilitation just for those pools to which the cue is applied, and then maintenance of this synaptic facilitation in just those pools when the cue is removed by the continuing neuronal firing in those pools. The findings have implications for understanding how several items can be maintained simultaneously in short term memory, how this may be relevant to the implementation of language in the brain, and suggest new approaches to understanding and treating the decline in short term memory that can occur with normal aging.Edmund T RollsLaura Dempere-MarcoGustavo DecoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61078 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edmund T Rolls Laura Dempere-Marco Gustavo Deco Holding multiple items in short term memory: a neural mechanism.
description	Human short term memory has a capacity of several items maintained simultaneously. We show how the number of short term memory representations that an attractor network modeling a cortical local network can simultaneously maintain active is increased by using synaptic facilitation of the type found in the prefrontal cortex. We have been able to maintain 9 short term memories active simultaneously in integrate-and-fire simulations where the proportion of neurons in each population, the sparseness, is 0.1, and have confirmed the stability of such a system with mean field analyses. Without synaptic facilitation the system can maintain many fewer memories active in the same network. The system operates because of the effectively increased synaptic strengths formed by the synaptic facilitation just for those pools to which the cue is applied, and then maintenance of this synaptic facilitation in just those pools when the cue is removed by the continuing neuronal firing in those pools. The findings have implications for understanding how several items can be maintained simultaneously in short term memory, how this may be relevant to the implementation of language in the brain, and suggest new approaches to understanding and treating the decline in short term memory that can occur with normal aging.
format	article
author	Edmund T Rolls Laura Dempere-Marco Gustavo Deco
author_facet	Edmund T Rolls Laura Dempere-Marco Gustavo Deco
author_sort	Edmund T Rolls
title	Holding multiple items in short term memory: a neural mechanism.
title_short	Holding multiple items in short term memory: a neural mechanism.
title_full	Holding multiple items in short term memory: a neural mechanism.
title_fullStr	Holding multiple items in short term memory: a neural mechanism.
title_full_unstemmed	Holding multiple items in short term memory: a neural mechanism.
title_sort	holding multiple items in short term memory: a neural mechanism.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f2df580f2aab4ab0886dfbd98a52ff3c
work_keys_str_mv	AT edmundtrolls holdingmultipleitemsinshorttermmemoryaneuralmechanism AT laurademperemarco holdingmultipleitemsinshorttermmemoryaneuralmechanism AT gustavodeco holdingmultipleitemsinshorttermmemoryaneuralmechanism
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Holding multiple items in short term memory: a neural mechanism.

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