Urinary stone composition analysis and clinical characterization of 1520 patients in central China

Abstract A total of 1520 patients with urinary stones from central China were collected and analysed by Fourier transform infrared spectroscopy between October 1, 2016 and December 31, 2019. For all patients, age, sex, comorbidities, stone location, laboratory examination and geographic region were...

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Autores principales:	Daling Zhang, Songchao Li, Zhengguo Zhang, Ningyang Li, Xiang Yuan, Zhankui Jia, Jinjian Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2df98415b9d49638d34da0c2d711d53
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spelling	oai:doaj.org-article:f2df98415b9d49638d34da0c2d711d532021-12-02T11:39:47ZUrinary stone composition analysis and clinical characterization of 1520 patients in central China10.1038/s41598-021-85723-32045-2322https://doaj.org/article/f2df98415b9d49638d34da0c2d711d532021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85723-3https://doaj.org/toc/2045-2322Abstract A total of 1520 patients with urinary stones from central China were collected and analysed by Fourier transform infrared spectroscopy between October 1, 2016 and December 31, 2019. For all patients, age, sex, comorbidities, stone location, laboratory examination and geographic region were collected. The most common stone component was calcium oxalate (77.5%), followed by calcium phosphate (8.7%), infection stone (7.6%), uric acid (UA) stone (5.3%)and cystine (0.9%). The males had more calcium oxalate stones (p < 0.001), while infection stone and cystine stones occurred more frequently in females (p < 0.001). The prevalence peak occurred at 41–60 years in both men and women. UA stones occurred frequently in patients with lower urinary pH (p < 0.001), while neutral urine or alkaline urine (p < 0.001) and urinary infection (p < 0.001) were more likely to be associated with infection stone stones. Patients with high levels of serum creatinine were more likely to develop UA stones (p < 0.001). The proportion of UA stones in diabetics was higher (p < 0.001), and the incidence of hypertension was higher in patients with UA stones (p < 0.001). Compared to the other types, more calcium oxalate stones were detected in the kidneys and ureters (p < 0.001), whereas struvite stones were more frequently observed in the lower urinary tract (p = 0.001). There was no significant difference in stone composition across the Qinling-Huaihe line in central China except UA stones, which were more frequently observed in patients south of the line (p < 0.001).Daling ZhangSongchao LiZhengguo ZhangNingyang LiXiang YuanZhankui JiaJinjian YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daling Zhang Songchao Li Zhengguo Zhang Ningyang Li Xiang Yuan Zhankui Jia Jinjian Yang Urinary stone composition analysis and clinical characterization of 1520 patients in central China
description	Abstract A total of 1520 patients with urinary stones from central China were collected and analysed by Fourier transform infrared spectroscopy between October 1, 2016 and December 31, 2019. For all patients, age, sex, comorbidities, stone location, laboratory examination and geographic region were collected. The most common stone component was calcium oxalate (77.5%), followed by calcium phosphate (8.7%), infection stone (7.6%), uric acid (UA) stone (5.3%)and cystine (0.9%). The males had more calcium oxalate stones (p < 0.001), while infection stone and cystine stones occurred more frequently in females (p < 0.001). The prevalence peak occurred at 41–60 years in both men and women. UA stones occurred frequently in patients with lower urinary pH (p < 0.001), while neutral urine or alkaline urine (p < 0.001) and urinary infection (p < 0.001) were more likely to be associated with infection stone stones. Patients with high levels of serum creatinine were more likely to develop UA stones (p < 0.001). The proportion of UA stones in diabetics was higher (p < 0.001), and the incidence of hypertension was higher in patients with UA stones (p < 0.001). Compared to the other types, more calcium oxalate stones were detected in the kidneys and ureters (p < 0.001), whereas struvite stones were more frequently observed in the lower urinary tract (p = 0.001). There was no significant difference in stone composition across the Qinling-Huaihe line in central China except UA stones, which were more frequently observed in patients south of the line (p < 0.001).
format	article
author	Daling Zhang Songchao Li Zhengguo Zhang Ningyang Li Xiang Yuan Zhankui Jia Jinjian Yang
author_facet	Daling Zhang Songchao Li Zhengguo Zhang Ningyang Li Xiang Yuan Zhankui Jia Jinjian Yang
author_sort	Daling Zhang
title	Urinary stone composition analysis and clinical characterization of 1520 patients in central China
title_short	Urinary stone composition analysis and clinical characterization of 1520 patients in central China
title_full	Urinary stone composition analysis and clinical characterization of 1520 patients in central China
title_fullStr	Urinary stone composition analysis and clinical characterization of 1520 patients in central China
title_full_unstemmed	Urinary stone composition analysis and clinical characterization of 1520 patients in central China
title_sort	urinary stone composition analysis and clinical characterization of 1520 patients in central china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2df98415b9d49638d34da0c2d711d53
work_keys_str_mv	AT dalingzhang urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT songchaoli urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT zhengguozhang urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT ningyangli urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT xiangyuan urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT zhankuijia urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina AT jinjianyang urinarystonecompositionanalysisandclinicalcharacterizationof1520patientsincentralchina
_version_	1718395738474414080

Urinary stone composition analysis and clinical characterization of 1520 patients in central China

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