Comparison between male and female breast cancer survival using propensity score matching analysis

Abstract Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival...

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Autores principales:	Serena Scomersi, Fabiola Giudici, Giuseppe Cacciatore, Pasquale Losurdo, Stefano Fracon, Sara Cortinovis, Rita Ceccherini, Fabrizio Zanconati, Maura Tonutti, Marina Bortul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2e26c2d1ce44e4fbd5d17137303fee2
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spelling	oai:doaj.org-article:f2e26c2d1ce44e4fbd5d17137303fee22021-12-02T15:56:41ZComparison between male and female breast cancer survival using propensity score matching analysis10.1038/s41598-021-91131-42045-2322https://doaj.org/article/f2e26c2d1ce44e4fbd5d17137303fee22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91131-4https://doaj.org/toc/2045-2322Abstract Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management.Serena ScomersiFabiola GiudiciGiuseppe CacciatorePasquale LosurdoStefano FraconSara CortinovisRita CeccheriniFabrizio ZanconatiMaura TonuttiMarina BortulNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Serena Scomersi Fabiola Giudici Giuseppe Cacciatore Pasquale Losurdo Stefano Fracon Sara Cortinovis Rita Ceccherini Fabrizio Zanconati Maura Tonutti Marina Bortul Comparison between male and female breast cancer survival using propensity score matching analysis
description	Abstract Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management.
format	article
author	Serena Scomersi Fabiola Giudici Giuseppe Cacciatore Pasquale Losurdo Stefano Fracon Sara Cortinovis Rita Ceccherini Fabrizio Zanconati Maura Tonutti Marina Bortul
author_facet	Serena Scomersi Fabiola Giudici Giuseppe Cacciatore Pasquale Losurdo Stefano Fracon Sara Cortinovis Rita Ceccherini Fabrizio Zanconati Maura Tonutti Marina Bortul
author_sort	Serena Scomersi
title	Comparison between male and female breast cancer survival using propensity score matching analysis
title_short	Comparison between male and female breast cancer survival using propensity score matching analysis
title_full	Comparison between male and female breast cancer survival using propensity score matching analysis
title_fullStr	Comparison between male and female breast cancer survival using propensity score matching analysis
title_full_unstemmed	Comparison between male and female breast cancer survival using propensity score matching analysis
title_sort	comparison between male and female breast cancer survival using propensity score matching analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2e26c2d1ce44e4fbd5d17137303fee2
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Comparison between male and female breast cancer survival using propensity score matching analysis

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