A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated S...

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Autores principales:	Giulia E. Tyzack, Claire E. Hall, Christopher R. Sibley, Tomasz Cymes, Serhiy Forostyak, Giulia Carlino, Ione F. Meyer, Giampietro Schiavo, Su-Chun Zhang, George M. Gibbons, Jia Newcombe, Rickie Patani, András Lakatos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2e3526b9f5c450291eab266e252c78a
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spelling	oai:doaj.org-article:f2e3526b9f5c450291eab266e252c78a2021-12-02T15:38:40ZA neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models10.1038/s41467-017-01283-z2041-1723https://doaj.org/article/f2e3526b9f5c450291eab266e252c78a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01283-zhttps://doaj.org/toc/2041-1723Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.Giulia E. TyzackClaire E. HallChristopher R. SibleyTomasz CymesSerhiy ForostyakGiulia CarlinoIone F. MeyerGiampietro SchiavoSu-Chun ZhangGeorge M. GibbonsJia NewcombeRickie PataniAndrás LakatosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia E. Tyzack Claire E. Hall Christopher R. Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino Ione F. Meyer Giampietro Schiavo Su-Chun Zhang George M. Gibbons Jia Newcombe Rickie Patani András Lakatos A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
description	Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.
format	article
author	Giulia E. Tyzack Claire E. Hall Christopher R. Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino Ione F. Meyer Giampietro Schiavo Su-Chun Zhang George M. Gibbons Jia Newcombe Rickie Patani András Lakatos
author_facet	Giulia E. Tyzack Claire E. Hall Christopher R. Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino Ione F. Meyer Giampietro Schiavo Su-Chun Zhang George M. Gibbons Jia Newcombe Rickie Patani András Lakatos
author_sort	Giulia E. Tyzack
title	A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
title_short	A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
title_full	A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
title_fullStr	A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
title_full_unstemmed	A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
title_sort	neuroprotective astrocyte state is induced by neuronal signal ephb1 but fails in als models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2e3526b9f5c450291eab266e252c78a
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A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

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