The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study

Peng Yu,1,2 Li Huang,1,2 Zhihan Wang,1,2 Xiaoyu Meng,1,2 Xuefeng Yu1,2 1Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2Branch of National Clinical Research Center for Metabolic Diseases, Hu...

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Autores principales:	Yu P, Huang L, Wang Z, Meng X, Yu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	uric acid beta-cell function insulin resistance nondiabetic Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f2e3f4a7bdcb4d14b7d0069d66cb1e93
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spelling	oai:doaj.org-article:f2e3f4a7bdcb4d14b7d0069d66cb1e932021-12-02T17:43:14ZThe Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study1178-7007https://doaj.org/article/f2e3f4a7bdcb4d14b7d0069d66cb1e932021-06-01T00:00:00Zhttps://www.dovepress.com/the-association-of-serum-uric-acid-with-beta-cell-function-and-insulin-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Peng Yu,1,2 Li Huang,1,2 Zhihan Wang,1,2 Xiaoyu Meng,1,2 Xuefeng Yu1,2 1Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2Branch of National Clinical Research Center for Metabolic Diseases, Hubei, ChinaCorrespondence: Xuefeng Yu Tel/Fax +8602783663331Email xfyu188@163.comPurpose: Higher serum levels of uric acid (SUA) are associated with an increased risk of developing type 2 diabetes. Meanwhile, insulin resistance and beta-cell dysfunction are critical factors that mediate the progression from normal glucose tolerance to impaired fasting glucose (IFG) and type 2 diabetes. We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes.Patients and Methods: We used cross-sectional data from the China Health and Nutrition Survey to examine the association. Insulin resistance and beta-cell dysfunction were estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index and homeostasis model assessment of beta-cell function (HOMA-beta) index, respectively. The associations were analyzed by using partial correlation analysis and multivariate logistic regressionl analysis.Results: SUA levels were positively associated with fasting glucose, fasting insulin, HOMA-IR in the total population. After adjustment for age, drinking, smoking, living area, daily dietary nutrient intake, body mass index (BMI), estimated glomerular filtration rate (eGFR), hypertension, and dyslipidemia, compared with participants in the lowest quartile of SUA, the adjusted odds ratios for the fourth quartiles were 1.56(1.09-2.24) for IFG, 1.51(1.27-1.78) for insulin resistance, and 1.06(0.88-1.27) for beta-cell dysfunction. In the subgroup analysis, no interactions were found between serum uric acid and age, drinking status, smoking status, BMI, hypertension, or dyslipidemia (all p for interaction> 0.05).Conclusion: In nondiabetic individuals, SUA levels are independently associated with IFG and insulin resistance, while no significant association exists between SUA and beta-cell dysfunction.Keywords: uric acid, beta-cell function, insulin resistance, nondiabeticYu PHuang LWang ZMeng XYu XDove Medical Pressarticleuric acidbeta-cell functioninsulin resistancenondiabeticSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2673-2682 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uric acid beta-cell function insulin resistance nondiabetic Specialties of internal medicine RC581-951
spellingShingle	uric acid beta-cell function insulin resistance nondiabetic Specialties of internal medicine RC581-951 Yu P Huang L Wang Z Meng X Yu X The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
description	Peng Yu,1,2 Li Huang,1,2 Zhihan Wang,1,2 Xiaoyu Meng,1,2 Xuefeng Yu1,2 1Department of Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2Branch of National Clinical Research Center for Metabolic Diseases, Hubei, ChinaCorrespondence: Xuefeng Yu Tel/Fax +8602783663331Email xfyu188@163.comPurpose: Higher serum levels of uric acid (SUA) are associated with an increased risk of developing type 2 diabetes. Meanwhile, insulin resistance and beta-cell dysfunction are critical factors that mediate the progression from normal glucose tolerance to impaired fasting glucose (IFG) and type 2 diabetes. We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes.Patients and Methods: We used cross-sectional data from the China Health and Nutrition Survey to examine the association. Insulin resistance and beta-cell dysfunction were estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index and homeostasis model assessment of beta-cell function (HOMA-beta) index, respectively. The associations were analyzed by using partial correlation analysis and multivariate logistic regressionl analysis.Results: SUA levels were positively associated with fasting glucose, fasting insulin, HOMA-IR in the total population. After adjustment for age, drinking, smoking, living area, daily dietary nutrient intake, body mass index (BMI), estimated glomerular filtration rate (eGFR), hypertension, and dyslipidemia, compared with participants in the lowest quartile of SUA, the adjusted odds ratios for the fourth quartiles were 1.56(1.09-2.24) for IFG, 1.51(1.27-1.78) for insulin resistance, and 1.06(0.88-1.27) for beta-cell dysfunction. In the subgroup analysis, no interactions were found between serum uric acid and age, drinking status, smoking status, BMI, hypertension, or dyslipidemia (all p for interaction> 0.05).Conclusion: In nondiabetic individuals, SUA levels are independently associated with IFG and insulin resistance, while no significant association exists between SUA and beta-cell dysfunction.Keywords: uric acid, beta-cell function, insulin resistance, nondiabetic
format	article
author	Yu P Huang L Wang Z Meng X Yu X
author_facet	Yu P Huang L Wang Z Meng X Yu X
author_sort	Yu P
title	The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
title_short	The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
title_full	The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
title_fullStr	The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
title_full_unstemmed	The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study
title_sort	association of serum uric acid with beta-cell function and insulin resistance in nondiabetic individuals: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f2e3f4a7bdcb4d14b7d0069d66cb1e93
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The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study

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