Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study.
Due to shortage of donor, kidney transplants (KTs) from donors with acute kidney injury (AKI) are expanding. Although previous studies comparing clinical outcomes between AKI and non-AKI donors in KTs have shown comparable results, data on high-volume analysis of KTs outcomes with AKI donors are lim...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f2e454bb5ab54e4d903ef33333dadad9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f2e454bb5ab54e4d903ef33333dadad9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f2e454bb5ab54e4d903ef33333dadad92021-12-02T20:14:54ZOutcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study.1932-620310.1371/journal.pone.0254115https://doaj.org/article/f2e454bb5ab54e4d903ef33333dadad92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254115https://doaj.org/toc/1932-6203Due to shortage of donor, kidney transplants (KTs) from donors with acute kidney injury (AKI) are expanding. Although previous studies comparing clinical outcomes between AKI and non-AKI donors in KTs have shown comparable results, data on high-volume analysis of KTs outcomes with AKI donors are limited. This study aimed to analyze the selection trends of AKI donors and investigate the impact of AKI on graft failure using the United states cohort data. We analyzed a total 52,757 KTs collected in the Scientific Registry of Transplant Recipient (SRTR) from 2010 to 2015. The sample included 4,962 (9.4%) cases of KTs with AKI donors (creatinine ≥ 2 mg/dL). Clinical characteristics of AKI and non-AKI donors were analyzed and outcomes of both groups were compared. We also analyzed risk factors for graft failure in AKI donor KTs. Although the incidence of delayed graft function was higher in recipients of AKI donors compared to non-AKI donors, graft and patient survival were not significantly different between the two groups. We found donor hypertension, cold ischemic time, the proportion of African American donors, and high KDPI were risk factors for graft failure in AKI donor KTs. KTs from deceased donor with AKI showed comparable outcomes. Thus, donors with AKI need to be considered more actively to expand donor pool. Caution is still needed when donors have additional risk factors of graft failure.Cheol Woong JungDana JorgensenPuneet SoodRajil MehtaMichele MolinariSundaram HariharanArmando GanozaDirk Van Der WindtMartin N WijkstromChethan M PuttarajappaAmit D TevarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254115 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Cheol Woong Jung Dana Jorgensen Puneet Sood Rajil Mehta Michele Molinari Sundaram Hariharan Armando Ganoza Dirk Van Der Windt Martin N Wijkstrom Chethan M Puttarajappa Amit D Tevar Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| description |
Due to shortage of donor, kidney transplants (KTs) from donors with acute kidney injury (AKI) are expanding. Although previous studies comparing clinical outcomes between AKI and non-AKI donors in KTs have shown comparable results, data on high-volume analysis of KTs outcomes with AKI donors are limited. This study aimed to analyze the selection trends of AKI donors and investigate the impact of AKI on graft failure using the United states cohort data. We analyzed a total 52,757 KTs collected in the Scientific Registry of Transplant Recipient (SRTR) from 2010 to 2015. The sample included 4,962 (9.4%) cases of KTs with AKI donors (creatinine ≥ 2 mg/dL). Clinical characteristics of AKI and non-AKI donors were analyzed and outcomes of both groups were compared. We also analyzed risk factors for graft failure in AKI donor KTs. Although the incidence of delayed graft function was higher in recipients of AKI donors compared to non-AKI donors, graft and patient survival were not significantly different between the two groups. We found donor hypertension, cold ischemic time, the proportion of African American donors, and high KDPI were risk factors for graft failure in AKI donor KTs. KTs from deceased donor with AKI showed comparable outcomes. Thus, donors with AKI need to be considered more actively to expand donor pool. Caution is still needed when donors have additional risk factors of graft failure. |
| format |
article |
| author |
Cheol Woong Jung Dana Jorgensen Puneet Sood Rajil Mehta Michele Molinari Sundaram Hariharan Armando Ganoza Dirk Van Der Windt Martin N Wijkstrom Chethan M Puttarajappa Amit D Tevar |
| author_facet |
Cheol Woong Jung Dana Jorgensen Puneet Sood Rajil Mehta Michele Molinari Sundaram Hariharan Armando Ganoza Dirk Van Der Windt Martin N Wijkstrom Chethan M Puttarajappa Amit D Tevar |
| author_sort |
Cheol Woong Jung |
| title |
Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| title_short |
Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| title_full |
Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| title_fullStr |
Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| title_full_unstemmed |
Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study. |
| title_sort |
outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-a retrospective cohort study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/f2e454bb5ab54e4d903ef33333dadad9 |
| work_keys_str_mv |
AT cheolwoongjung outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT danajorgensen outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT puneetsood outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT rajilmehta outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT michelemolinari outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT sundaramhariharan outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT armandoganoza outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT dirkvanderwindt outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT martinnwijkstrom outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT chethanmputtarajappa outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy AT amitdtevar outcomesandfactorsleadingtograftfailureinkidneytransplantsfromdeceaseddonorswithacutekidneyinjuryaretrospectivecohortstudy |
| _version_ |
1718374680702746624 |