Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation

Abstract Hypertension is a well-known late effect of hematopoietic cell transplantation (HCT), but no markers predicting its development are known. Our aim was to assess short-term blood pressure (BP) values and expressions of hypertension-associated genes as possible markers of hypertension in chil...

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Autores principales:	Wojciech Strojny, Kinga Kwiecińska, Kamil Fijorek, Michał Korostyński, Marcin Piechota, Walentyna Balwierz, Szymon Skoczeń
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2e7b39f0d0f47dc9c4f79194a643eb3
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spelling	oai:doaj.org-article:f2e7b39f0d0f47dc9c4f79194a643eb32021-12-02T16:55:45ZComparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation10.1038/s41598-021-88848-72045-2322https://doaj.org/article/f2e7b39f0d0f47dc9c4f79194a643eb32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88848-7https://doaj.org/toc/2045-2322Abstract Hypertension is a well-known late effect of hematopoietic cell transplantation (HCT), but no markers predicting its development are known. Our aim was to assess short-term blood pressure (BP) values and expressions of hypertension-associated genes as possible markers of hypertension in children treated with HCT. We measured systolic blood pressure (SBP) and diastolic blood pressure (DBP), using both office procedure and ambulatory BP monitoring (ABPM) in children before HCT and after a median of 6 months after HCT. We compared the results with two control groups, one of healthy children and another of children with simple obesity. We also performed microarray analysis of hypertension-associated genes in patients treated with HCT and children with obesity. We found no significant differences in SBP and DBP in patients before and after HCT. We found significant differences in expressions of certain genes in patients treated with HCT compared with children with obesity. We concluded that BP values in short-term follow-up after HCT do not seem to be useful predictors of hypertension as a late effect of HCT. However, over expressions of certain hypertension-associated genes might be used as markers of hypertension as a late effect of HCT if this is confirmed in larger long-term studies.Wojciech StrojnyKinga KwiecińskaKamil FijorekMichał KorostyńskiMarcin PiechotaWalentyna BalwierzSzymon SkoczeńNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wojciech Strojny Kinga Kwiecińska Kamil Fijorek Michał Korostyński Marcin Piechota Walentyna Balwierz Szymon Skoczeń Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
description	Abstract Hypertension is a well-known late effect of hematopoietic cell transplantation (HCT), but no markers predicting its development are known. Our aim was to assess short-term blood pressure (BP) values and expressions of hypertension-associated genes as possible markers of hypertension in children treated with HCT. We measured systolic blood pressure (SBP) and diastolic blood pressure (DBP), using both office procedure and ambulatory BP monitoring (ABPM) in children before HCT and after a median of 6 months after HCT. We compared the results with two control groups, one of healthy children and another of children with simple obesity. We also performed microarray analysis of hypertension-associated genes in patients treated with HCT and children with obesity. We found no significant differences in SBP and DBP in patients before and after HCT. We found significant differences in expressions of certain genes in patients treated with HCT compared with children with obesity. We concluded that BP values in short-term follow-up after HCT do not seem to be useful predictors of hypertension as a late effect of HCT. However, over expressions of certain hypertension-associated genes might be used as markers of hypertension as a late effect of HCT if this is confirmed in larger long-term studies.
format	article
author	Wojciech Strojny Kinga Kwiecińska Kamil Fijorek Michał Korostyński Marcin Piechota Walentyna Balwierz Szymon Skoczeń
author_facet	Wojciech Strojny Kinga Kwiecińska Kamil Fijorek Michał Korostyński Marcin Piechota Walentyna Balwierz Szymon Skoczeń
author_sort	Wojciech Strojny
title	Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
title_short	Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
title_full	Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
title_fullStr	Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
title_full_unstemmed	Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
title_sort	comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2e7b39f0d0f47dc9c4f79194a643eb3
work_keys_str_mv	AT wojciechstrojny comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT kingakwiecinska comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT kamilfijorek comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT michałkorostynski comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT marcinpiechota comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT walentynabalwierz comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation AT szymonskoczen comparisonofbloodpressurevaluesandexpressionofgenesassociatedwithhypertensioninchildrenbeforeandafterhematopoieticcelltransplantation
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Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation

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