Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.

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Auteurs principaux:	Eran Assaraf, Ronen Blecher, Lia Heinemann-Yerushalmi, Sharon Krief, Ron Carmel Vinestock, Inbal E. Biton, Vlad Brumfeld, Ron Rotkopf, Erez Avisar, Gabriel Agar, Elazar Zelzer
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f2eadef4102943bfaa0c0612f6af5ecb
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spelling	oai:doaj.org-article:f2eadef4102943bfaa0c0612f6af5ecb2021-12-02T17:12:24ZPiezo2 expressed in proprioceptive neurons is essential for skeletal integrity10.1038/s41467-020-16971-62041-1723https://doaj.org/article/f2eadef4102943bfaa0c0612f6af5ecb2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16971-6https://doaj.org/toc/2041-1723Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.Eran AssarafRonen BlecherLia Heinemann-YerushalmiSharon KriefRon Carmel VinestockInbal E. BitonVlad BrumfeldRon RotkopfErez AvisarGabriel AgarElazar ZelzerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eran Assaraf Ronen Blecher Lia Heinemann-Yerushalmi Sharon Krief Ron Carmel Vinestock Inbal E. Biton Vlad Brumfeld Ron Rotkopf Erez Avisar Gabriel Agar Elazar Zelzer Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
description	Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.
format	article
author	Eran Assaraf Ronen Blecher Lia Heinemann-Yerushalmi Sharon Krief Ron Carmel Vinestock Inbal E. Biton Vlad Brumfeld Ron Rotkopf Erez Avisar Gabriel Agar Elazar Zelzer
author_facet	Eran Assaraf Ronen Blecher Lia Heinemann-Yerushalmi Sharon Krief Ron Carmel Vinestock Inbal E. Biton Vlad Brumfeld Ron Rotkopf Erez Avisar Gabriel Agar Elazar Zelzer
author_sort	Eran Assaraf
title	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
title_short	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
title_full	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
title_fullStr	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
title_full_unstemmed	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
title_sort	piezo2 expressed in proprioceptive neurons is essential for skeletal integrity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f2eadef4102943bfaa0c0612f6af5ecb
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Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

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