Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding

Patient Blood Management advocates an individualized treatment approach, tailored to each patient’s needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high importance when it comes to critical care patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Friederike S. Neuenfeldt, Markus A. Weigand, Dania Fischer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coagulopathy coagulation bleeding critical care Medicine R
Acceso en línea:	https://doaj.org/article/f2eb9d61982941bcbdc5acc6eabbdd1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2eb9d61982941bcbdc5acc6eabbdd1b
record_format	dspace
spelling	oai:doaj.org-article:f2eb9d61982941bcbdc5acc6eabbdd1b2021-11-25T18:02:19ZCoagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding10.3390/jcm102253692077-0383https://doaj.org/article/f2eb9d61982941bcbdc5acc6eabbdd1b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5369https://doaj.org/toc/2077-0383Patient Blood Management advocates an individualized treatment approach, tailored to each patient’s needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high importance when it comes to critical care patients, as coagulopathies are a common phenomenon among them and may significantly impact morbidity and mortality. Treating coagulopathies is complex as thrombotic and hemorrhagic conditions may coexist and the medications at hand to modulate hemostasis can be powerful. The cornerstones of coagulation management are an appropriate patient evaluation, including the individual risk of bleeding weighed against the risk of thrombosis, a proper diagnostic work-up of the coagulopathy’s etiology, treatment with targeted therapies, and transfusion of blood product components when clinically indicated in a goal-directed manner. In this article, we will outline various reasons for coagulopathy in critical care patients to highlight the aspects that need special consideration. The treatment options outlined in this article include anticoagulation, anticoagulant reversal, clotting factor concentrates, antifibrinolytic agents, desmopressin, fresh frozen plasma, and platelets. This article outlines concepts with the aim of the minimization of complications associated with coagulopathies in critically ill patients. Hereditary coagulopathies will be omitted in this review.Friederike S. NeuenfeldtMarkus A. WeigandDania FischerMDPI AGarticlecoagulopathycoagulationbleedingcritical careMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5369, p 5369 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coagulopathy coagulation bleeding critical care Medicine R
spellingShingle	coagulopathy coagulation bleeding critical care Medicine R Friederike S. Neuenfeldt Markus A. Weigand Dania Fischer Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
description	Patient Blood Management advocates an individualized treatment approach, tailored to each patient’s needs, in order to reduce unnecessary exposure to allogeneic blood products. The optimization of hemostasis and minimization of blood loss is of high importance when it comes to critical care patients, as coagulopathies are a common phenomenon among them and may significantly impact morbidity and mortality. Treating coagulopathies is complex as thrombotic and hemorrhagic conditions may coexist and the medications at hand to modulate hemostasis can be powerful. The cornerstones of coagulation management are an appropriate patient evaluation, including the individual risk of bleeding weighed against the risk of thrombosis, a proper diagnostic work-up of the coagulopathy’s etiology, treatment with targeted therapies, and transfusion of blood product components when clinically indicated in a goal-directed manner. In this article, we will outline various reasons for coagulopathy in critical care patients to highlight the aspects that need special consideration. The treatment options outlined in this article include anticoagulation, anticoagulant reversal, clotting factor concentrates, antifibrinolytic agents, desmopressin, fresh frozen plasma, and platelets. This article outlines concepts with the aim of the minimization of complications associated with coagulopathies in critically ill patients. Hereditary coagulopathies will be omitted in this review.
format	article
author	Friederike S. Neuenfeldt Markus A. Weigand Dania Fischer
author_facet	Friederike S. Neuenfeldt Markus A. Weigand Dania Fischer
author_sort	Friederike S. Neuenfeldt
title	Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
title_short	Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
title_full	Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
title_fullStr	Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
title_full_unstemmed	Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding
title_sort	coagulopathies in intensive care medicine: balancing act between thrombosis and bleeding
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2eb9d61982941bcbdc5acc6eabbdd1b
work_keys_str_mv	AT friederikesneuenfeldt coagulopathiesinintensivecaremedicinebalancingactbetweenthrombosisandbleeding AT markusaweigand coagulopathiesinintensivecaremedicinebalancingactbetweenthrombosisandbleeding AT daniafischer coagulopathiesinintensivecaremedicinebalancingactbetweenthrombosisandbleeding
_version_	1718411717099126784

Coagulopathies in Intensive Care Medicine: Balancing Act between Thrombosis and Bleeding

Ejemplares similares