Ileal transposition in surgical treatment for type 2 diabetes mellitus

High prevalence and insufficient efficacy of medical treatment in type 2 diabetes mellitus (T2DM) poses a major challenge for medical care. Generally, only 30% of patients reach therapeutic goals, while remission occurs only in the minority of patients. In the obese (BMI>35 kg/m2), bariatric surg...

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Autores principales:	Oleg Viktorovich Kornyushin, Mikhail Michailovich Galagudza, Alexander Evgen'evich Neymark, Alina Yur'evna Grineva, Elena Nikolaevna Babenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	diabetes mellitus incretins ileal transposition bariatric surgery Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f2ec8cab73f34f0b943233c65732d453
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id	oai:doaj.org-article:f2ec8cab73f34f0b943233c65732d453
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spelling	oai:doaj.org-article:f2ec8cab73f34f0b943233c65732d4532021-11-14T09:00:19ZIleal transposition in surgical treatment for type 2 diabetes mellitus2072-03512072-037810.14341/DM2015158-64https://doaj.org/article/f2ec8cab73f34f0b943233c65732d4532015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6741https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378High prevalence and insufficient efficacy of medical treatment in type 2 diabetes mellitus (T2DM) poses a major challenge for medical care. Generally, only 30% of patients reach therapeutic goals, while remission occurs only in the minority of patients. In the obese (BMI>35 kg/m2), bariatric surgery provides an alternative to pharmacological treatment of T2DM, boosting remission/compensation rate up to 76.8%. A few recent clinical studies explored the anti-diabetic effect of ileal transposition (IT). This type of surgery targets restoration of incretin balance by proximal transposition of ileal segment. In this review, we discuss the salutary mechanisms of IT in T2DM based on the analysis of the pioneering clinical trials.Oleg Viktorovich KornyushinMikhail Michailovich GalagudzaAlexander Evgen'evich NeymarkAlina Yur'evna GrinevaElena Nikolaevna BabenkoEndocrinology Research Centrearticlediabetes mellitusincretinsileal transpositionbariatric surgeryNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 58-64 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus incretins ileal transposition bariatric surgery Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus incretins ileal transposition bariatric surgery Nutritional diseases. Deficiency diseases RC620-627 Oleg Viktorovich Kornyushin Mikhail Michailovich Galagudza Alexander Evgen'evich Neymark Alina Yur'evna Grineva Elena Nikolaevna Babenko Ileal transposition in surgical treatment for type 2 diabetes mellitus
description	High prevalence and insufficient efficacy of medical treatment in type 2 diabetes mellitus (T2DM) poses a major challenge for medical care. Generally, only 30% of patients reach therapeutic goals, while remission occurs only in the minority of patients. In the obese (BMI>35 kg/m2), bariatric surgery provides an alternative to pharmacological treatment of T2DM, boosting remission/compensation rate up to 76.8%. A few recent clinical studies explored the anti-diabetic effect of ileal transposition (IT). This type of surgery targets restoration of incretin balance by proximal transposition of ileal segment. In this review, we discuss the salutary mechanisms of IT in T2DM based on the analysis of the pioneering clinical trials.
format	article
author	Oleg Viktorovich Kornyushin Mikhail Michailovich Galagudza Alexander Evgen'evich Neymark Alina Yur'evna Grineva Elena Nikolaevna Babenko
author_facet	Oleg Viktorovich Kornyushin Mikhail Michailovich Galagudza Alexander Evgen'evich Neymark Alina Yur'evna Grineva Elena Nikolaevna Babenko
author_sort	Oleg Viktorovich Kornyushin
title	Ileal transposition in surgical treatment for type 2 diabetes mellitus
title_short	Ileal transposition in surgical treatment for type 2 diabetes mellitus
title_full	Ileal transposition in surgical treatment for type 2 diabetes mellitus
title_fullStr	Ileal transposition in surgical treatment for type 2 diabetes mellitus
title_full_unstemmed	Ileal transposition in surgical treatment for type 2 diabetes mellitus
title_sort	ileal transposition in surgical treatment for type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/f2ec8cab73f34f0b943233c65732d453
work_keys_str_mv	AT olegviktorovichkornyushin ilealtranspositioninsurgicaltreatmentfortype2diabetesmellitus AT mikhailmichailovichgalagudza ilealtranspositioninsurgicaltreatmentfortype2diabetesmellitus AT alexanderevgenevichneymark ilealtranspositioninsurgicaltreatmentfortype2diabetesmellitus AT alinayurevnagrineva ilealtranspositioninsurgicaltreatmentfortype2diabetesmellitus AT elenanikolaevnababenko ilealtranspositioninsurgicaltreatmentfortype2diabetesmellitus
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Ileal transposition in surgical treatment for type 2 diabetes mellitus

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