In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community

Antimicrobial resistance genes are often associated with integrons, which promote their movement between and within DNA molecules. IntFinder 1.0 and I-VIP v1.2 were used for the detection of integrons and their associated resistance genes in assembled sequences and raw reads. A dataset comprising 16...

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Autores principales:	Lilibeth Torres-Elizalde, David Ortega-Paredes, Karen Loaiza, Esteban Fernández-Moreira, Marco Larrea-Álvarez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Salmonella enterica</i> class 1 and 2 integrons <i>dfrA</i> genes bioinformatic tools IntFinder Andean Community Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f2eda604186c4d7fa8ee4cd406431f70
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spelling	oai:doaj.org-article:f2eda604186c4d7fa8ee4cd406431f702021-11-25T16:24:34ZIn Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community10.3390/antibiotics101113882079-6382https://doaj.org/article/f2eda604186c4d7fa8ee4cd406431f702021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1388https://doaj.org/toc/2079-6382Antimicrobial resistance genes are often associated with integrons, which promote their movement between and within DNA molecules. IntFinder 1.0 and I-VIP v1.2 were used for the detection of integrons and their associated resistance genes in assembled sequences and raw reads. A dataset comprising 1688 sequenced <i>Salmonella enterica</i> isolates from countries of the Andean Community was developed. A total of 749 and 680 integrons were identified by IntFinder 1.0 and I-VIP v1.2, respectively; class 2 integrons were the most abundant followed by class 1, whereas no class 3 integrons were detected. These elements were mainly associated with isolates from animal sources. <i>S.</i> Infantis ST32 contained the majority of integrons. Trimethoprim resistance genes (<i>dfrA</i>) were found in greater numbers than others, including <i>aadA</i> and <i>bla</i> genes. The presence of these resistance integrons may come as a response to antibiotic misuse, especially of co-trimoxazole. This represents a public health risk as novel resistant strains might appear due to gene dissemination. The information gathered from in silico studies not only contributes to our understanding of integron dynamics in pathogenic <i>Salmonella</i>, but also helps identify potential emergent patterns of resistance in the region, which is fundamental for developing pertinent antibiotic surveillance programs.Lilibeth Torres-ElizaldeDavid Ortega-ParedesKaren LoaizaEsteban Fernández-MoreiraMarco Larrea-ÁlvarezMDPI AGarticle<i>Salmonella enterica</i>class 1 and 2 integrons<i>dfrA</i> genesbioinformatic toolsIntFinderAndean CommunityTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1388, p 1388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Salmonella enterica</i> class 1 and 2 integrons <i>dfrA</i> genes bioinformatic tools IntFinder Andean Community Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Salmonella enterica</i> class 1 and 2 integrons <i>dfrA</i> genes bioinformatic tools IntFinder Andean Community Therapeutics. Pharmacology RM1-950 Lilibeth Torres-Elizalde David Ortega-Paredes Karen Loaiza Esteban Fernández-Moreira Marco Larrea-Álvarez In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
description	Antimicrobial resistance genes are often associated with integrons, which promote their movement between and within DNA molecules. IntFinder 1.0 and I-VIP v1.2 were used for the detection of integrons and their associated resistance genes in assembled sequences and raw reads. A dataset comprising 1688 sequenced <i>Salmonella enterica</i> isolates from countries of the Andean Community was developed. A total of 749 and 680 integrons were identified by IntFinder 1.0 and I-VIP v1.2, respectively; class 2 integrons were the most abundant followed by class 1, whereas no class 3 integrons were detected. These elements were mainly associated with isolates from animal sources. <i>S.</i> Infantis ST32 contained the majority of integrons. Trimethoprim resistance genes (<i>dfrA</i>) were found in greater numbers than others, including <i>aadA</i> and <i>bla</i> genes. The presence of these resistance integrons may come as a response to antibiotic misuse, especially of co-trimoxazole. This represents a public health risk as novel resistant strains might appear due to gene dissemination. The information gathered from in silico studies not only contributes to our understanding of integron dynamics in pathogenic <i>Salmonella</i>, but also helps identify potential emergent patterns of resistance in the region, which is fundamental for developing pertinent antibiotic surveillance programs.
format	article
author	Lilibeth Torres-Elizalde David Ortega-Paredes Karen Loaiza Esteban Fernández-Moreira Marco Larrea-Álvarez
author_facet	Lilibeth Torres-Elizalde David Ortega-Paredes Karen Loaiza Esteban Fernández-Moreira Marco Larrea-Álvarez
author_sort	Lilibeth Torres-Elizalde
title	In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
title_short	In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
title_full	In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
title_fullStr	In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
title_full_unstemmed	In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community
title_sort	in silico detection of antimicrobial resistance integrons in <i>salmonella enterica</i> isolates from countries of the andean community
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2eda604186c4d7fa8ee4cd406431f70
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In Silico Detection of Antimicrobial Resistance Integrons in <i>Salmonella enterica</i> Isolates from Countries of the Andean Community

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