Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes

Abstract The center of the fovea, termed the foveola, is the area of highest visual acuity, has the highest density of cone photoreceptors. We investigated the distance between the automatically-determined center of the foveal avascular zone (FAZ) and the manually-determined highest foveal bulge (FB...

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Autores principales:	Takuhei Shoji, Hirokazu Ishii, Junji Kanno, Takanori Sasaki, Yuji Yoshikawa, Hisashi Ibuki, Kei Shinoda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2edfe86190d479fb73db20d38d24538
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spelling	oai:doaj.org-article:f2edfe86190d479fb73db20d38d245382021-11-08T10:48:35ZDistance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes10.1038/s41598-021-00826-12045-2322https://doaj.org/article/f2edfe86190d479fb73db20d38d245382021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00826-1https://doaj.org/toc/2045-2322Abstract The center of the fovea, termed the foveola, is the area of highest visual acuity, has the highest density of cone photoreceptors. We investigated the distance between the automatically-determined center of the foveal avascular zone (FAZ) and the manually-determined highest foveal bulge (FB) point using single swept-source optical coherence tomography angiography (OCTA) instrument. This cross-sectional study included 49 eyes of 49 individuals (34 women and 15 men; median age: 68 years) with no history of ocular disorders. The FAZ in the superficial capillary plexus was automatically determined using the Kanno–Saitama macro method, and the center of the FAZ was automatically determined using ellipse approximation. Another candidate foveal center, the highest FB point, was determined manually on the serial cross-sectional B-scan images. As a result, the foveal center was manually identified as the highest FB point on B-scan OCTA images. The center of the FAZ was more likely to be located inferior to the highest FB point (p = 0.031). In participants with a total (linear) distance of more than 50 μm between the center of the FAZ and the highest FB point, the displacement was significantly more in the horizontal direction than in the vertical direction (p = 0.017). These results can be applicable to further studies regarding the spatial relationships between the center of the FAZ and the highest FB point in various macular diseases or previously-treated eyes.Takuhei ShojiHirokazu IshiiJunji KannoTakanori SasakiYuji YoshikawaHisashi IbukiKei ShinodaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takuhei Shoji Hirokazu Ishii Junji Kanno Takanori Sasaki Yuji Yoshikawa Hisashi Ibuki Kei Shinoda Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
description	Abstract The center of the fovea, termed the foveola, is the area of highest visual acuity, has the highest density of cone photoreceptors. We investigated the distance between the automatically-determined center of the foveal avascular zone (FAZ) and the manually-determined highest foveal bulge (FB) point using single swept-source optical coherence tomography angiography (OCTA) instrument. This cross-sectional study included 49 eyes of 49 individuals (34 women and 15 men; median age: 68 years) with no history of ocular disorders. The FAZ in the superficial capillary plexus was automatically determined using the Kanno–Saitama macro method, and the center of the FAZ was automatically determined using ellipse approximation. Another candidate foveal center, the highest FB point, was determined manually on the serial cross-sectional B-scan images. As a result, the foveal center was manually identified as the highest FB point on B-scan OCTA images. The center of the FAZ was more likely to be located inferior to the highest FB point (p = 0.031). In participants with a total (linear) distance of more than 50 μm between the center of the FAZ and the highest FB point, the displacement was significantly more in the horizontal direction than in the vertical direction (p = 0.017). These results can be applicable to further studies regarding the spatial relationships between the center of the FAZ and the highest FB point in various macular diseases or previously-treated eyes.
format	article
author	Takuhei Shoji Hirokazu Ishii Junji Kanno Takanori Sasaki Yuji Yoshikawa Hisashi Ibuki Kei Shinoda
author_facet	Takuhei Shoji Hirokazu Ishii Junji Kanno Takanori Sasaki Yuji Yoshikawa Hisashi Ibuki Kei Shinoda
author_sort	Takuhei Shoji
title	Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
title_short	Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
title_full	Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
title_fullStr	Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
title_full_unstemmed	Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes
title_sort	distance between the center of the faz measured automatically and the highest foveal bulge using oct-angiography in elderly healthy eyes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2edfe86190d479fb73db20d38d24538
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Distance between the center of the FAZ measured automatically and the highest foveal bulge using OCT-angiography in elderly healthy eyes

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