Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses

Abstract Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Siamak Farajzadeh Khosroshahi, Xianzhen Yin, Cornelius K. Donat, Aisling McGarry, Maria Yanez Lopez, Nicoleta Baxan, David J. Sharp, Magdalena Sastre, Mazdak Ghajari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2efa6704f3f4516bbe0dcb5ad727f87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2efa6704f3f4516bbe0dcb5ad727f87
record_format	dspace
spelling	oai:doaj.org-article:f2efa6704f3f4516bbe0dcb5ad727f872021-12-02T18:02:54ZMultiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses10.1038/s41598-021-92371-02045-2322https://doaj.org/article/f2efa6704f3f4516bbe0dcb5ad727f872021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92371-0https://doaj.org/toc/2045-2322Abstract Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood–brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention.Siamak Farajzadeh KhosroshahiXianzhen YinCornelius K. DonatAisling McGarryMaria Yanez LopezNicoleta BaxanDavid J. SharpMagdalena SastreMazdak GhajariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siamak Farajzadeh Khosroshahi Xianzhen Yin Cornelius K. Donat Aisling McGarry Maria Yanez Lopez Nicoleta Baxan David J. Sharp Magdalena Sastre Mazdak Ghajari Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
description	Abstract Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. We developed a high-fidelity multiscale finite element model of the rat brain featuring a detailed definition of the angioarchitecture. Controlled cortical impacts were performed experimentally and in-silico. The model was able to predict the pattern of blood–brain barrier damage. We found strong correlation between the area of fibrinogen extravasation and the brain area where axial strain in vessels exceeds 0.14. Our results showed that adjacent vessels can sustain profoundly different axial stresses depending on their alignment with the principal direction of stress in parenchyma, with a better alignment leading to larger stresses in vessels. We also found a strong correlation between axial stress in vessels and the shearing component of the stress wave in parenchyma. Our multiscale computational approach explains the unrecognised role of the vascular anatomy and shear stresses in producing distinct distribution of large forces in vasculature. This new understanding can contribute to improving TBI diagnosis and prevention.
format	article
author	Siamak Farajzadeh Khosroshahi Xianzhen Yin Cornelius K. Donat Aisling McGarry Maria Yanez Lopez Nicoleta Baxan David J. Sharp Magdalena Sastre Mazdak Ghajari
author_facet	Siamak Farajzadeh Khosroshahi Xianzhen Yin Cornelius K. Donat Aisling McGarry Maria Yanez Lopez Nicoleta Baxan David J. Sharp Magdalena Sastre Mazdak Ghajari
author_sort	Siamak Farajzadeh Khosroshahi
title	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
title_short	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
title_full	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
title_fullStr	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
title_full_unstemmed	Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
title_sort	multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2efa6704f3f4516bbe0dcb5ad727f87
work_keys_str_mv	AT siamakfarajzadehkhosroshahi multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT xianzhenyin multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT corneliuskdonat multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT aislingmcgarry multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT mariayanezlopez multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT nicoletabaxan multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT davidjsharp multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT magdalenasastre multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses AT mazdakghajari multiscalemodellingofcerebrovascularinjuryrevealstheroleofvascularanatomyandparenchymalshearstresses
_version_	1718378844002451456

Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses

Ejemplares similares