The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
Lung paraffin sections of 35 died during the epidemic of influenza A/H1N1 of 2009-2010 in Zabaikalskiy krai were investigated. Exudative stage was diagnosed, in 10 cases, proliferative stage - in 16 cases and fibrotic stage of acute respiratory distress syndrome (ARDS) was diagnosed in 9 cases at th...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
Scientific Сentre for Family Health and Human Reproduction Problems
2013
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f2f1dd4db7a8444dbf56d59eec571637 |
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| Sumario: | Lung paraffin sections of 35 died during the epidemic of influenza A/H1N1 of 2009-2010 in Zabaikalskiy krai were investigated. Exudative stage was diagnosed, in 10 cases, proliferative stage - in 16 cases and fibrotic stage of acute respiratory distress syndrome (ARDS) was diagnosed in 9 cases at the autopsy. Expression of heat shock protein 70 (HSP-70) by cells of the lungs was determined in sections by immunohistochemistry. We revealed that HSP-70 is expressed by neutrophils, macrophages, fibroblasts and alveolocytes type 1 and. 2. It was found that regardless of the stage of ARDS the highest expression of HSP-70 was realized by neutrophils, the lowest - by the endothelium alveolocytes type 2 and. fibroblasts. HSP-70 expression in neutrophils, macrophages, fibroblasts and. alveolocytes type 1 was the same in all stages of ARDS. In alveolocytes type 2 in exudative and. proliferative phases it was lower than at the development of fibrosis. We concluded that one of the mechanisms of developments of acute lungs injury/acute respiratory distress syndrome at influenza pneumonia is comparatively low synthesis of HSP-70 by endotheliocytes of lung capillary and. alveolocytes type 2. |
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