The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia

Lung paraffin sections of 35 died during the epidemic of influenza A/H1N1 of 2009-2010 in Zabaikalskiy krai were investigated. Exudative stage was diagnosed, in 10 cases, proliferative stage - in 16 cases and fibrotic stage of acute respiratory distress syndrome (ARDS) was diagnosed in 9 cases at th...

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Autores principales:	E. V. Prutkina, A. V. Sepp, N. N. Tsybikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	hsp-70 pneumonia acute respiratory distress syndrome influenza a/h1n1 Science Q
Acceso en línea:	https://doaj.org/article/f2f1dd4db7a8444dbf56d59eec571637
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spelling	oai:doaj.org-article:f2f1dd4db7a8444dbf56d59eec5716372021-11-23T06:14:27ZThe role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia2541-94202587-9596https://doaj.org/article/f2f1dd4db7a8444dbf56d59eec5716372013-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1530https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Lung paraffin sections of 35 died during the epidemic of influenza A/H1N1 of 2009-2010 in Zabaikalskiy krai were investigated. Exudative stage was diagnosed, in 10 cases, proliferative stage - in 16 cases and fibrotic stage of acute respiratory distress syndrome (ARDS) was diagnosed in 9 cases at the autopsy. Expression of heat shock protein 70 (HSP-70) by cells of the lungs was determined in sections by immunohistochemistry. We revealed that HSP-70 is expressed by neutrophils, macrophages, fibroblasts and alveolocytes type 1 and. 2. It was found that regardless of the stage of ARDS the highest expression of HSP-70 was realized by neutrophils, the lowest - by the endothelium alveolocytes type 2 and. fibroblasts. HSP-70 expression in neutrophils, macrophages, fibroblasts and. alveolocytes type 1 was the same in all stages of ARDS. In alveolocytes type 2 in exudative and. proliferative phases it was lower than at the development of fibrosis. We concluded that one of the mechanisms of developments of acute lungs injury/acute respiratory distress syndrome at influenza pneumonia is comparatively low synthesis of HSP-70 by endotheliocytes of lung capillary and. alveolocytes type 2.E. V. PrutkinaA. V. SeppN. N. TsybikovScientific Сentre for Family Health and Human Reproduction Problemsarticlehsp-70pneumoniaacute respiratory distress syndromeinfluenza a/h1n1hsp-70ScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2(1), Pp 71-75 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	hsp-70 pneumonia acute respiratory distress syndrome influenza a/h1n1 hsp-70 Science Q
spellingShingle	hsp-70 pneumonia acute respiratory distress syndrome influenza a/h1n1 hsp-70 Science Q E. V. Prutkina A. V. Sepp N. N. Tsybikov The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
description	Lung paraffin sections of 35 died during the epidemic of influenza A/H1N1 of 2009-2010 in Zabaikalskiy krai were investigated. Exudative stage was diagnosed, in 10 cases, proliferative stage - in 16 cases and fibrotic stage of acute respiratory distress syndrome (ARDS) was diagnosed in 9 cases at the autopsy. Expression of heat shock protein 70 (HSP-70) by cells of the lungs was determined in sections by immunohistochemistry. We revealed that HSP-70 is expressed by neutrophils, macrophages, fibroblasts and alveolocytes type 1 and. 2. It was found that regardless of the stage of ARDS the highest expression of HSP-70 was realized by neutrophils, the lowest - by the endothelium alveolocytes type 2 and. fibroblasts. HSP-70 expression in neutrophils, macrophages, fibroblasts and. alveolocytes type 1 was the same in all stages of ARDS. In alveolocytes type 2 in exudative and. proliferative phases it was lower than at the development of fibrosis. We concluded that one of the mechanisms of developments of acute lungs injury/acute respiratory distress syndrome at influenza pneumonia is comparatively low synthesis of HSP-70 by endotheliocytes of lung capillary and. alveolocytes type 2.
format	article
author	E. V. Prutkina A. V. Sepp N. N. Tsybikov
author_facet	E. V. Prutkina A. V. Sepp N. N. Tsybikov
author_sort	E. V. Prutkina
title	The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
title_short	The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
title_full	The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
title_fullStr	The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
title_full_unstemmed	The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
title_sort	role of hsp-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/f2f1dd4db7a8444dbf56d59eec571637
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The role of HSP-70 in the pathogenesis of respiratory distress syndrome induced by influenza pneumonia

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