A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma

Although various platelet-rich plasma (PRP) kits are commercially available, the efficacy of these kits for knee osteoarthritis (KOA) has not been fully investigated. This study aimed to investigate the short-term results of leukocyte-poor PRP (LP-PRP) and the factors that contribute to its efficacy...

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Autores principales:	Naoya Kikuchi, Tomokazu Yoshioka, Norihito Arai, Hisashi Sugaya, Kojiro Hyodo, Yu Taniguchi, Kosuke Okuno, Akihiro Kanamori, Masashi Yamazaki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	plasma rich in growth factor platelet-rich plasma knee osteoarthritis Medicine R
Acceso en línea:	https://doaj.org/article/f2f502971cf84134a9d1cbfba74ad638
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spelling	oai:doaj.org-article:f2f502971cf84134a9d1cbfba74ad6382021-11-11T17:44:31ZA Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma10.3390/jcm102151212077-0383https://doaj.org/article/f2f502971cf84134a9d1cbfba74ad6382021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5121https://doaj.org/toc/2077-0383Although various platelet-rich plasma (PRP) kits are commercially available, the efficacy of these kits for knee osteoarthritis (KOA) has not been fully investigated. This study aimed to investigate the short-term results of leukocyte-poor PRP (LP-PRP) and the factors that contribute to its efficacy. We retrospectively reviewed 124 patients with KOA who were treated with LP-PRP. White blood cell (WBC) and platelet counts in the whole blood and the LP-PRP were measured. KOA severity was assessed using radiography. Clinical evaluation was performed both prior to injection and after an average of 3.3 weeks after the injection using the Japanese Knee Osteoarthritis Measure (JKOM). Responders were defined based on the JKOM. The contributing factors for responders were examined using a multivariate logistic analysis. The responder rate was 58.1% and the contributing factors for responders were a higher visual analog scale score before injection, WBC count in whole blood, and platelet concentration ratio of LP-PRP. The LP-PRP improved the clinical scores in the short term. Certain patient characteristics before injection and the concentration ratio of LP-PRP may be predictors of its efficacy; these may provide clues for elucidating which components of LP-PRP act on KOA pathologies.Naoya KikuchiTomokazu YoshiokaNorihito AraiHisashi SugayaKojiro HyodoYu TaniguchiKosuke OkunoAkihiro KanamoriMasashi YamazakiMDPI AGarticleplasma rich in growth factorplatelet-rich plasmaknee osteoarthritisMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5121, p 5121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasma rich in growth factor platelet-rich plasma knee osteoarthritis Medicine R
spellingShingle	plasma rich in growth factor platelet-rich plasma knee osteoarthritis Medicine R Naoya Kikuchi Tomokazu Yoshioka Norihito Arai Hisashi Sugaya Kojiro Hyodo Yu Taniguchi Kosuke Okuno Akihiro Kanamori Masashi Yamazaki A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
description	Although various platelet-rich plasma (PRP) kits are commercially available, the efficacy of these kits for knee osteoarthritis (KOA) has not been fully investigated. This study aimed to investigate the short-term results of leukocyte-poor PRP (LP-PRP) and the factors that contribute to its efficacy. We retrospectively reviewed 124 patients with KOA who were treated with LP-PRP. White blood cell (WBC) and platelet counts in the whole blood and the LP-PRP were measured. KOA severity was assessed using radiography. Clinical evaluation was performed both prior to injection and after an average of 3.3 weeks after the injection using the Japanese Knee Osteoarthritis Measure (JKOM). Responders were defined based on the JKOM. The contributing factors for responders were examined using a multivariate logistic analysis. The responder rate was 58.1% and the contributing factors for responders were a higher visual analog scale score before injection, WBC count in whole blood, and platelet concentration ratio of LP-PRP. The LP-PRP improved the clinical scores in the short term. Certain patient characteristics before injection and the concentration ratio of LP-PRP may be predictors of its efficacy; these may provide clues for elucidating which components of LP-PRP act on KOA pathologies.
format	article
author	Naoya Kikuchi Tomokazu Yoshioka Norihito Arai Hisashi Sugaya Kojiro Hyodo Yu Taniguchi Kosuke Okuno Akihiro Kanamori Masashi Yamazaki
author_facet	Naoya Kikuchi Tomokazu Yoshioka Norihito Arai Hisashi Sugaya Kojiro Hyodo Yu Taniguchi Kosuke Okuno Akihiro Kanamori Masashi Yamazaki
author_sort	Naoya Kikuchi
title	A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
title_short	A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
title_full	A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
title_fullStr	A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
title_full_unstemmed	A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma
title_sort	retrospective analysis of clinical outcome and predictive factors for responders with knee osteoarthritis to a single injection of leukocyte-poor platelet-rich plasma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2f502971cf84134a9d1cbfba74ad638
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A Retrospective Analysis of Clinical Outcome and Predictive Factors for Responders with Knee Osteoarthritis to a Single Injection of Leukocyte-Poor Platelet-Rich Plasma

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