A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience
Context Nilotinib is a second-generation BCR-ABL1 tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML). Aims We aim to evaluate the responses and safety of upfront Nilotinib therapy in Indian CML patients. Setting and Design We retrospectively revie...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2021
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oai:doaj.org-article:f2f652b4c4ca41589504fa425f5e33b72021-11-25T01:50:29ZA Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience2278-330X2278-430610.1055/s-0041-1733301https://doaj.org/article/f2f652b4c4ca41589504fa425f5e33b72021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1733301https://doaj.org/toc/2278-330Xhttps://doaj.org/toc/2278-4306Context Nilotinib is a second-generation BCR-ABL1 tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML). Aims We aim to evaluate the responses and safety of upfront Nilotinib therapy in Indian CML patients. Setting and Design We retrospectively reviewed the medical records of CML patients who received Nilotinib as an upfront treatment at our center between January 1, 2011 and October 15, 2019.The follow-up was taken till March 31, 2020. Results Forty One patients (n = 36 chronic phase and five accelerated-phase CML) received frontline Nilotinib. Median age was 39 years (21–63) with male-to-female ratio of 1.1: 1. At 3 months, 96.9% patients achieved BCR-ABL of ≤10% at international scale. By the end of 12 months, 71.5% patients achieved major molecular response (BCR-ABL ≤0.1%) and 91.4% patients achieved complete cytogenetic response assessed by BCR-ABL polymerase chain reaction of ≤1%. Common toxicities observed were weight gain, thrombocytopenia, corrected QT prolongation, and elevated serum amylase in 14 (34.1%), 7(17.07%), 4(9.7%), and 4(9.7%) patients, respectively. Overall, five patients had loss of response with further progression and death in three patients. At a median of 43.7 months, 38 patients survived with estimated 3 year event-free survival and overall survival of 65 ± 9 and 93 ± 5%. Conclusion This study showed remarkable good response with upfront Nilotinib in Indian patients with CML.Reema SinghJyotsna KapoorRayaz AhmedPallavi MehtaVishvdeep KhushooPragya AgrawalDinesh BhuraniNarendra AgrawalThieme Medical and Scientific Publishers Pvt. Ltd.articleupfront nilotinibearly molecular responsemajor molecular responsechronic myeloid leukemiatoxicityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENSouth Asian Journal of Cancer (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
upfront nilotinib early molecular response major molecular response chronic myeloid leukemia toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
upfront nilotinib early molecular response major molecular response chronic myeloid leukemia toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Reema Singh Jyotsna Kapoor Rayaz Ahmed Pallavi Mehta Vishvdeep Khushoo Pragya Agrawal Dinesh Bhurani Narendra Agrawal A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| description |
Context Nilotinib is a second-generation BCR-ABL1 tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML).
Aims We aim to evaluate the responses and safety of upfront Nilotinib therapy in Indian CML patients.
Setting and Design We retrospectively reviewed the medical records of CML patients who received Nilotinib as an upfront treatment at our center between January 1, 2011 and October 15, 2019.The follow-up was taken till March 31, 2020.
Results Forty One patients (n = 36 chronic phase and five accelerated-phase CML) received frontline Nilotinib. Median age was 39 years (21–63) with male-to-female ratio of 1.1: 1. At 3 months, 96.9% patients achieved BCR-ABL of ≤10% at international scale. By the end of 12 months, 71.5% patients achieved major molecular response (BCR-ABL ≤0.1%) and 91.4% patients achieved complete cytogenetic response assessed by BCR-ABL polymerase chain reaction of ≤1%. Common toxicities observed were weight gain, thrombocytopenia, corrected QT prolongation, and elevated serum amylase in 14 (34.1%), 7(17.07%), 4(9.7%), and 4(9.7%) patients, respectively. Overall, five patients had loss of response with further progression and death in three patients. At a median of 43.7 months, 38 patients survived with estimated 3 year event-free survival and overall survival of 65 ± 9 and 93 ± 5%.
Conclusion This study showed remarkable good response with upfront Nilotinib in Indian patients with CML. |
| format |
article |
| author |
Reema Singh Jyotsna Kapoor Rayaz Ahmed Pallavi Mehta Vishvdeep Khushoo Pragya Agrawal Dinesh Bhurani Narendra Agrawal |
| author_facet |
Reema Singh Jyotsna Kapoor Rayaz Ahmed Pallavi Mehta Vishvdeep Khushoo Pragya Agrawal Dinesh Bhurani Narendra Agrawal |
| author_sort |
Reema Singh |
| title |
A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| title_short |
A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| title_full |
A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| title_fullStr |
A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| title_full_unstemmed |
A Retrospective Cohort Study of Upfront Nilotinib in Chronic Myeloid Leukemia: A Single-Center Experience |
| title_sort |
retrospective cohort study of upfront nilotinib in chronic myeloid leukemia: a single-center experience |
| publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f2f652b4c4ca41589504fa425f5e33b7 |
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