EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS

Background: A polyamine, agmatine, has been proposed as a new neurotransmitter in the brain. Objective: The aim of this study was to evaluate the effects of acute and chronic agmatine treatment on the rat auditory system. Methods: Male Wistar albino rats weighing between 280-330 grams were use...

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Autores principales:	Özlem Saatci, Burcu Çevreli, Tayfun Uzbay
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	neurootology neuropharmacology neuropathology Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f2f6db3cf022484cbdb083336c362740
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spelling	oai:doaj.org-article:f2f6db3cf022484cbdb083336c3627402021-11-24T05:05:36ZEFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS10.21776/ub.mnj.2021.007.02.12407-67242442-5001https://doaj.org/article/f2f6db3cf022484cbdb083336c3627402021-07-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/498https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: A polyamine, agmatine, has been proposed as a new neurotransmitter in the brain. Objective: The aim of this study was to evaluate the effects of acute and chronic agmatine treatment on the rat auditory system. Methods: Male Wistar albino rats weighing between 280-330 grams were used. Animals were divided into four groups (n= 8 for each group). Acute and chronic agmatine (160 mg/kg) was administered to rats. Prepulse inhibition (PPI) of the acoustic startle reflex (ASR), distortion product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABR) were evaluated in all groups. Results: Both acute and chronic agmatine treatments also significantly disrupted PPI. Chronic but not acute treatment with agmatine produced some DPOAE and ABR changes in rats. Conclusion: Our results suggested that chronic agmatine treatment for seven days resulted in some significant negative changes in cochlear function. Because the PPI of the ASR is also used as an indicator for psychoses, such as schizophrenia, in human and experimental animal studies, our findings also imply that the DPOAE and ABR tests may also be considered in the diagnosis and follow-up of patients with psychoses.Özlem SaatciBurcu ÇevreliTayfun UzbayUniversity of BrawijayaarticleneurootologyneuropharmacologyneuropathologyMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 2, Pp 85-92 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	neurootology neuropharmacology neuropathology Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neurootology neuropharmacology neuropathology Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Özlem Saatci Burcu Çevreli Tayfun Uzbay EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
description	Background: A polyamine, agmatine, has been proposed as a new neurotransmitter in the brain. Objective: The aim of this study was to evaluate the effects of acute and chronic agmatine treatment on the rat auditory system. Methods: Male Wistar albino rats weighing between 280-330 grams were used. Animals were divided into four groups (n= 8 for each group). Acute and chronic agmatine (160 mg/kg) was administered to rats. Prepulse inhibition (PPI) of the acoustic startle reflex (ASR), distortion product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABR) were evaluated in all groups. Results: Both acute and chronic agmatine treatments also significantly disrupted PPI. Chronic but not acute treatment with agmatine produced some DPOAE and ABR changes in rats. Conclusion: Our results suggested that chronic agmatine treatment for seven days resulted in some significant negative changes in cochlear function. Because the PPI of the ASR is also used as an indicator for psychoses, such as schizophrenia, in human and experimental animal studies, our findings also imply that the DPOAE and ABR tests may also be considered in the diagnosis and follow-up of patients with psychoses.
format	article
author	Özlem Saatci Burcu Çevreli Tayfun Uzbay
author_facet	Özlem Saatci Burcu Çevreli Tayfun Uzbay
author_sort	Özlem Saatci
title	EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
title_short	EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
title_full	EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
title_fullStr	EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
title_full_unstemmed	EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
title_sort	effects of agmatine on acoustic startle reflex and auditory system in rats
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/f2f6db3cf022484cbdb083336c362740
work_keys_str_mv	AT ozlemsaatci effectsofagmatineonacousticstartlereflexandauditorysysteminrats AT burcucevreli effectsofagmatineonacousticstartlereflexandauditorysysteminrats AT tayfunuzbay effectsofagmatineonacousticstartlereflexandauditorysysteminrats
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EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS

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