Human adipose glycerol flux is regulated by a pH gate in AQP10

Human adipose glycerol flux is regulated by a pH gate in AQP10

Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipolysis is coupled to AQP10 regulation in

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Autores principales: Kamil Gotfryd, Andreia Filipa Mósca, Julie Winkel Missel, Sigurd Friis Truelsen, Kaituo Wang, Mariana Spulber, Simon Krabbe, Claus Hélix-Nielsen, Umberto Laforenza, Graça Soveral, Per Amstrup Pedersen, Pontus Gourdon
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f2f9e79e53f4454685084cc268e265dc
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spelling oai:doaj.org-article:f2f9e79e53f4454685084cc268e265dc2021-12-02T15:34:23ZHuman adipose glycerol flux is regulated by a pH gate in AQP1010.1038/s41467-018-07176-z2041-1723https://doaj.org/article/f2f9e79e53f4454685084cc268e265dc2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07176-zhttps://doaj.org/toc/2041-1723Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipolysis is coupled to AQP10 regulation inKamil GotfrydAndreia Filipa MóscaJulie Winkel MisselSigurd Friis TruelsenKaituo WangMariana SpulberSimon KrabbeClaus Hélix-NielsenUmberto LaforenzaGraça SoveralPer Amstrup PedersenPontus GourdonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kamil Gotfryd
Andreia Filipa Mósca
Julie Winkel Missel
Sigurd Friis Truelsen
Kaituo Wang
Mariana Spulber
Simon Krabbe
Claus Hélix-Nielsen
Umberto Laforenza
Graça Soveral
Per Amstrup Pedersen
Pontus Gourdon
Human adipose glycerol flux is regulated by a pH gate in AQP10
description Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipolysis is coupled to AQP10 regulation in
format article
author Kamil Gotfryd
Andreia Filipa Mósca
Julie Winkel Missel
Sigurd Friis Truelsen
Kaituo Wang
Mariana Spulber
Simon Krabbe
Claus Hélix-Nielsen
Umberto Laforenza
Graça Soveral
Per Amstrup Pedersen
Pontus Gourdon
author_facet Kamil Gotfryd
Andreia Filipa Mósca
Julie Winkel Missel
Sigurd Friis Truelsen
Kaituo Wang
Mariana Spulber
Simon Krabbe
Claus Hélix-Nielsen
Umberto Laforenza
Graça Soveral
Per Amstrup Pedersen
Pontus Gourdon
author_sort Kamil Gotfryd
title Human adipose glycerol flux is regulated by a pH gate in AQP10
title_short Human adipose glycerol flux is regulated by a pH gate in AQP10
title_full Human adipose glycerol flux is regulated by a pH gate in AQP10
title_fullStr Human adipose glycerol flux is regulated by a pH gate in AQP10
title_full_unstemmed Human adipose glycerol flux is regulated by a pH gate in AQP10
title_sort human adipose glycerol flux is regulated by a ph gate in aqp10
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f2f9e79e53f4454685084cc268e265dc
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