Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune res...

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Auteurs principaux: Esther D Quakkelaar, Anke Redeker, Elias K Haddad, Alexandre Harari, Stella Mayo McCaughey, Thomas Duhen, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nikki M Loof, Ferry Ossendorp, Beatriz Perdiguero, Paul Heinen, Carmen E Gomez, Karen V Kibler, David M Koelle, Rafick P Sékaly, Federica Sallusto, Antonio Lanzavecchia, Giuseppe Pantaleo, Mariano Esteban, Jim Tartaglia, Bertram L Jacobs, Cornelis J M Melief
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/f2fa053478d04f77baca2398b5125f5a
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https://doaj.org/article/f2fa053478d04f77baca2398b5125f5a

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