Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome

Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with other trans-acting effects, including disruption...

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Autores principales:	He Fang, Giancarlo Bonora, Jordan P. Lewandowski, Jitendra Thakur, Galina N. Filippova, Steven Henikoff, Jay Shendure, Zhijun Duan, John L. Rinn, Xinxian Deng, William S. Noble, Christine M. Disteche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2fa1372c67040d5a7985930598deed0
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spelling	oai:doaj.org-article:f2fa1372c67040d5a7985930598deed02021-12-02T14:42:29ZTrans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome10.1038/s41467-020-19879-32041-1723https://doaj.org/article/f2fa1372c67040d5a7985930598deed02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19879-3https://doaj.org/toc/2041-1723Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with other trans-acting effects, including disruption of the perinuclear location and minor dysregulation of gene expression.He FangGiancarlo BonoraJordan P. LewandowskiJitendra ThakurGalina N. FilippovaSteven HenikoffJay ShendureZhijun DuanJohn L. RinnXinxian DengWilliam S. NobleChristine M. DistecheNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q He Fang Giancarlo Bonora Jordan P. Lewandowski Jitendra Thakur Galina N. Filippova Steven Henikoff Jay Shendure Zhijun Duan John L. Rinn Xinxian Deng William S. Noble Christine M. Disteche Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
description	Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with other trans-acting effects, including disruption of the perinuclear location and minor dysregulation of gene expression.
format	article
author	He Fang Giancarlo Bonora Jordan P. Lewandowski Jitendra Thakur Galina N. Filippova Steven Henikoff Jay Shendure Zhijun Duan John L. Rinn Xinxian Deng William S. Noble Christine M. Disteche
author_facet	He Fang Giancarlo Bonora Jordan P. Lewandowski Jitendra Thakur Galina N. Filippova Steven Henikoff Jay Shendure Zhijun Duan John L. Rinn Xinxian Deng William S. Noble Christine M. Disteche
author_sort	He Fang
title	Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
title_short	Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
title_full	Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
title_fullStr	Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
title_full_unstemmed	Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
title_sort	trans- and cis-acting effects of firre on epigenetic features of the inactive x chromosome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f2fa1372c67040d5a7985930598deed0
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Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome

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