Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoid...

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Autores principales:	Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Elena V. Flisyuk, Alexander N. Shikov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anti-inflammatory cream drug release formulation development fucoidan topical application Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f2facc0b916543f2ac1474a920373d8f
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spelling	oai:doaj.org-article:f2facc0b916543f2ac1474a920373d8f2021-11-25T18:13:02ZFormulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties10.3390/md191106431660-3397https://doaj.org/article/f2facc0b916543f2ac1474a920373d8f2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/643https://doaj.org/toc/1660-3397Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its anti-inflammatory potential after topical application in vivo. Fucoidan from <i>Fucus vesiculosus</i> L. was used. The cream base consisting of olive oil and Kolliphor RH40 was optimized followed by in vitro agar diffusion and drug release studies. The fucoidan-based cream with 13% Kolliphor P 407, 1% Transcutol P, and 5% PEG400 showed good spreadability, washability, and colloidal stability, and it did not irritate the skin. The kinetics of fucoidan release from the optimized cream exhibited the best fit to the Korsmeyer–Peppas and Higuchi models with <i>R</i><sup>2</sup> > 0.99. Fucoidan release was controlled by drug diffusion and anomalous transport provided by the optimized cream base. The formulation was stable and provided high fucoidan release after storage for 1 year. Topical application of the fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia in rats. The efficacy of the fucoidan-based cream at a high dose was comparable with the efficacy of diclofenac gel. The fucoidan-based cream could be considered a promising anti-inflammatory formulation.Ekaterina D. ObluchinskayaOlga N. PozharitskayaElena V. FlisyukAlexander N. ShikovMDPI AGarticleanti-inflammatorycreamdrug releaseformulation developmentfucoidantopical applicationBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 643, p 643 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-inflammatory cream drug release formulation development fucoidan topical application Biology (General) QH301-705.5
spellingShingle	anti-inflammatory cream drug release formulation development fucoidan topical application Biology (General) QH301-705.5 Ekaterina D. Obluchinskaya Olga N. Pozharitskaya Elena V. Flisyuk Alexander N. Shikov Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
description	Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention. Due to several advantages of formulations for topical application, this study aimed to develop and optimize a fucoidan-based cream formulation and to investigate its anti-inflammatory potential after topical application in vivo. Fucoidan from <i>Fucus vesiculosus</i> L. was used. The cream base consisting of olive oil and Kolliphor RH40 was optimized followed by in vitro agar diffusion and drug release studies. The fucoidan-based cream with 13% Kolliphor P 407, 1% Transcutol P, and 5% PEG400 showed good spreadability, washability, and colloidal stability, and it did not irritate the skin. The kinetics of fucoidan release from the optimized cream exhibited the best fit to the Korsmeyer–Peppas and Higuchi models with <i>R</i><sup>2</sup> > 0.99. Fucoidan release was controlled by drug diffusion and anomalous transport provided by the optimized cream base. The formulation was stable and provided high fucoidan release after storage for 1 year. Topical application of the fucoidan-based cream dose-dependently inhibited carrageenan-induced edema and ameliorated mechanical allodynia in rats. The efficacy of the fucoidan-based cream at a high dose was comparable with the efficacy of diclofenac gel. The fucoidan-based cream could be considered a promising anti-inflammatory formulation.
format	article
author	Ekaterina D. Obluchinskaya Olga N. Pozharitskaya Elena V. Flisyuk Alexander N. Shikov
author_facet	Ekaterina D. Obluchinskaya Olga N. Pozharitskaya Elena V. Flisyuk Alexander N. Shikov
author_sort	Ekaterina D. Obluchinskaya
title	Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
title_short	Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
title_full	Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
title_fullStr	Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
title_full_unstemmed	Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties
title_sort	formulation, optimization and in vivo evaluation of fucoidan-based cream with anti-inflammatory properties
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2facc0b916543f2ac1474a920373d8f
work_keys_str_mv	AT ekaterinadobluchinskaya formulationoptimizationandinvivoevaluationoffucoidanbasedcreamwithantiinflammatoryproperties AT olganpozharitskaya formulationoptimizationandinvivoevaluationoffucoidanbasedcreamwithantiinflammatoryproperties AT elenavflisyuk formulationoptimizationandinvivoevaluationoffucoidanbasedcreamwithantiinflammatoryproperties AT alexandernshikov formulationoptimizationandinvivoevaluationoffucoidanbasedcreamwithantiinflammatoryproperties
_version_	1718411475930841088

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

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