A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.

Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The...

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Autores principales:	Alfredo Cruz-Ramírez, Sara Díaz-Triviño, Guy Wachsman, Yujuan Du, Mario Arteága-Vázquez, Hongtao Zhang, Rene Benjamins, Ikram Blilou, Anne B Neef, Vicki Chandler, Ben Scheres
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f2fc713b81f848daa05eedeffa1a6a5b
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spelling	oai:doaj.org-article:f2fc713b81f848daa05eedeffa1a6a5b2021-11-18T05:37:42ZA SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.1544-91731545-788510.1371/journal.pbio.1001724https://doaj.org/article/f2fc713b81f848daa05eedeffa1a6a5b2013-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24302889/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage.Alfredo Cruz-RamírezSara Díaz-TriviñoGuy WachsmanYujuan DuMario Arteága-VázquezHongtao ZhangRene BenjaminsIkram BlilouAnne B NeefVicki ChandlerBen ScheresPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 11, Iss 11, p e1001724 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alfredo Cruz-Ramírez Sara Díaz-Triviño Guy Wachsman Yujuan Du Mario Arteága-Vázquez Hongtao Zhang Rene Benjamins Ikram Blilou Anne B Neef Vicki Chandler Ben Scheres A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
description	Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage.
format	article
author	Alfredo Cruz-Ramírez Sara Díaz-Triviño Guy Wachsman Yujuan Du Mario Arteága-Vázquez Hongtao Zhang Rene Benjamins Ikram Blilou Anne B Neef Vicki Chandler Ben Scheres
author_facet	Alfredo Cruz-Ramírez Sara Díaz-Triviño Guy Wachsman Yujuan Du Mario Arteága-Vázquez Hongtao Zhang Rene Benjamins Ikram Blilou Anne B Neef Vicki Chandler Ben Scheres
author_sort	Alfredo Cruz-Ramírez
title	A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
title_short	A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
title_full	A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
title_fullStr	A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
title_full_unstemmed	A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
title_sort	scarecrow-retinoblastoma protein network controls protective quiescence in the arabidopsis root stem cell organizer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f2fc713b81f848daa05eedeffa1a6a5b
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A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.

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