SPECC1L-deficient primary mouse embryonic palatal mesenchyme cells show speed and directionality defects
Abstract Cleft lip and/or palate (CL/P) are common anomalies occurring in 1/800 live-births. Pathogenic SPECC1L variants have been identified in patients with CL/P, which signifies a primary role for SPECC1L in craniofacial development. Specc1l mutant mouse embryos exhibit delayed palatal shelf elev...
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Autores principales: | Jeremy P. Goering, Dona G. Isai, Everett G. Hall, Nathan R. Wilson, Edina Kosa, Luke W. Wenger, Zaid Umar, Abdul Yousaf, Andras Czirok, Irfan Saadi |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/f2fdb4bc38df495ea530b8f2277c226b |
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