Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review

BackgroundBasal ganglia germ cell tumors (BGGCTs) represent an extremely rare subset of tumors about which little is known. Some patients suffer from tumor dissemination, such as sellar involvement. This study aimed to evaluate the independent prognostic risk factors of patients with BGGCTs with or...

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Autores principales:	Yi Zhang, Li Wang, Wenbin Ma, Hui Pan, Renzhi Wang, Huijuan Zhu, Yong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	basal ganglia germ cell tumors sellar involvement delayed diagnosis independent prognostic risk factors surgical therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f302d5cff0884fc1bd1515c79f5fd7c4
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spelling	oai:doaj.org-article:f302d5cff0884fc1bd1515c79f5fd7c42021-11-10T15:15:58ZBasal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review1664-239210.3389/fendo.2021.763609https://doaj.org/article/f302d5cff0884fc1bd1515c79f5fd7c42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.763609/fullhttps://doaj.org/toc/1664-2392BackgroundBasal ganglia germ cell tumors (BGGCTs) represent an extremely rare subset of tumors about which little is known. Some patients suffer from tumor dissemination, such as sellar involvement. This study aimed to evaluate the independent prognostic risk factors of patients with BGGCTs with or without sellar involvement.MethodsSixteen patients were diagnosed with BGGCTs at Peking Union Medical College Hospital from January 2000 to December 2020. A literature review was performed on the online databases Medline and PubMed, and 76 cases in the 19 retrieved articles were identified at the same time. The data regarding biochemical tests, radiological examinations, and outcomes during follow-up were analyzed.ResultsOf 92 patients in this study, seven patients were clinically diagnosed as germinomas, with the remaining 85 patients receiving surgery. Fifty-two patients suffered from multifocal lesions or tumor dissemination. The patients with BGGCTs demonstrated a significant male predilection. The patients with delayed diagnosis more likely had cognitive disturbance (p = 0.028), mental disturbance (p = 0.047), and diabetes insipidus (p = 0.02). Multivariate analysis demonstrated that the independent poor prognostic risk factors of patients with BGGCTs were delayed diagnosis [odd ratio (OR) 2.33; 95% CI 1.02–5.31], focal radiotherapy (OR 4.00; 95% CI 1.69–9.49), and non-pure germinoma (OR 4.64; 95% CI 1.76–12.22).ConclusionsThe delayed diagnosis, focal radiotherapy, and non-pure germinoma were associated with a poorer prognosis for patients with BGGCTs with or without sellar involvement.Yi ZhangLi WangWenbin MaHui PanRenzhi WangHuijuan ZhuYong YaoFrontiers Media S.A.articlebasal ganglia germ cell tumorssellar involvementdelayed diagnosisindependent prognostic risk factorssurgical therapyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal ganglia germ cell tumors sellar involvement delayed diagnosis independent prognostic risk factors surgical therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	basal ganglia germ cell tumors sellar involvement delayed diagnosis independent prognostic risk factors surgical therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yi Zhang Li Wang Wenbin Ma Hui Pan Renzhi Wang Huijuan Zhu Yong Yao Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
description	BackgroundBasal ganglia germ cell tumors (BGGCTs) represent an extremely rare subset of tumors about which little is known. Some patients suffer from tumor dissemination, such as sellar involvement. This study aimed to evaluate the independent prognostic risk factors of patients with BGGCTs with or without sellar involvement.MethodsSixteen patients were diagnosed with BGGCTs at Peking Union Medical College Hospital from January 2000 to December 2020. A literature review was performed on the online databases Medline and PubMed, and 76 cases in the 19 retrieved articles were identified at the same time. The data regarding biochemical tests, radiological examinations, and outcomes during follow-up were analyzed.ResultsOf 92 patients in this study, seven patients were clinically diagnosed as germinomas, with the remaining 85 patients receiving surgery. Fifty-two patients suffered from multifocal lesions or tumor dissemination. The patients with BGGCTs demonstrated a significant male predilection. The patients with delayed diagnosis more likely had cognitive disturbance (p = 0.028), mental disturbance (p = 0.047), and diabetes insipidus (p = 0.02). Multivariate analysis demonstrated that the independent poor prognostic risk factors of patients with BGGCTs were delayed diagnosis [odd ratio (OR) 2.33; 95% CI 1.02–5.31], focal radiotherapy (OR 4.00; 95% CI 1.69–9.49), and non-pure germinoma (OR 4.64; 95% CI 1.76–12.22).ConclusionsThe delayed diagnosis, focal radiotherapy, and non-pure germinoma were associated with a poorer prognosis for patients with BGGCTs with or without sellar involvement.
format	article
author	Yi Zhang Li Wang Wenbin Ma Hui Pan Renzhi Wang Huijuan Zhu Yong Yao
author_facet	Yi Zhang Li Wang Wenbin Ma Hui Pan Renzhi Wang Huijuan Zhu Yong Yao
author_sort	Yi Zhang
title	Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
title_short	Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
title_full	Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
title_fullStr	Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
title_full_unstemmed	Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review
title_sort	basal ganglia germ cell tumors with or without sellar involvement: a long-term follow-up in a single medical center and a systematic literature review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f302d5cff0884fc1bd1515c79f5fd7c4
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Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review

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