Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate...

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Autores principales:	Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa
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spelling	oai:doaj.org-article:f305df8cd6b34e51b15c496289d931fa2021-12-02T18:53:14ZIntegrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth10.1038/s41598-021-96374-92045-2322https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96374-9https://doaj.org/toc/2045-2322Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic predisposition, our objective was to identify genetic and transcriptomic evidence of heat shock proteins and nuclear hormone receptors that may affect risk for SPTB. We investigated all 97 genes encoding members of the heat shock protein families and all 49 genes encoding nuclear hormone receptors for their potential role in SPTB susceptibility. We used multiple genetic and genomic datasets including genome-wide association studies (GWASs), whole-exome sequencing (WES), and placental transcriptomics to identify SPTB predisposing factors from the mother, infant, and placenta. There were multiple associations of heat shock protein and nuclear hormone receptor genes with SPTB. Several orthogonal datasets supported roles for SEC63, HSPA1L, SACS, RORA, and AR in susceptibility to SPTB. We propose that suppression of specific heat shock proteins promotes maintenance of pregnancy, whereas activation of specific heat shock protein mediated signaling may disturb maternal–fetal tolerance and promote labor.Johanna M. HuuskoHeli TiensuuAntti M. HaapalainenAnu PasanenPinja TissarinenMinna K. KarjalainenGe ZhangKaare ChristensenKelli K. RyckmanBo JacobssonJeffrey C. MurrayStephen F. KingsmoreMikko HallmanLouis J. MugliaMika RämetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johanna M. Huusko Heli Tiensuu Antti M. Haapalainen Anu Pasanen Pinja Tissarinen Minna K. Karjalainen Ge Zhang Kaare Christensen Kelli K. Ryckman Bo Jacobsson Jeffrey C. Murray Stephen F. Kingsmore Mikko Hallman Louis J. Muglia Mika Rämet Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
description	Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic predisposition, our objective was to identify genetic and transcriptomic evidence of heat shock proteins and nuclear hormone receptors that may affect risk for SPTB. We investigated all 97 genes encoding members of the heat shock protein families and all 49 genes encoding nuclear hormone receptors for their potential role in SPTB susceptibility. We used multiple genetic and genomic datasets including genome-wide association studies (GWASs), whole-exome sequencing (WES), and placental transcriptomics to identify SPTB predisposing factors from the mother, infant, and placenta. There were multiple associations of heat shock protein and nuclear hormone receptor genes with SPTB. Several orthogonal datasets supported roles for SEC63, HSPA1L, SACS, RORA, and AR in susceptibility to SPTB. We propose that suppression of specific heat shock proteins promotes maintenance of pregnancy, whereas activation of specific heat shock protein mediated signaling may disturb maternal–fetal tolerance and promote labor.
format	article
author	Johanna M. Huusko Heli Tiensuu Antti M. Haapalainen Anu Pasanen Pinja Tissarinen Minna K. Karjalainen Ge Zhang Kaare Christensen Kelli K. Ryckman Bo Jacobsson Jeffrey C. Murray Stephen F. Kingsmore Mikko Hallman Louis J. Muglia Mika Rämet
author_facet	Johanna M. Huusko Heli Tiensuu Antti M. Haapalainen Anu Pasanen Pinja Tissarinen Minna K. Karjalainen Ge Zhang Kaare Christensen Kelli K. Ryckman Bo Jacobsson Jeffrey C. Murray Stephen F. Kingsmore Mikko Hallman Louis J. Muglia Mika Rämet
author_sort	Johanna M. Huusko
title	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
title_short	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
title_full	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
title_fullStr	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
title_full_unstemmed	Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
title_sort	integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa
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Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth

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