Adipokines in metabolic processes regulating during obesity treatment

Bariatric surgery serves as a model for the assessment of the relationship between body mass index (BMI) reduction and changes in adipokine production and for exploring the endocrine function of the pancreas in patients who do not have the proximal part of the small intestine. Aim. of the study wa...

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Autores principales:	Larisa Sergeevna Litvinova, Maria Alexandrovna Vasilenko, Pavel Anatol'evich Zatolokin, Natalya Nikolaevna Aksenova, Nikolay Sergeevich Fattakhov, Igor Zinov'evich Vaysbeyn, Natalya Ivanovna Mironyuk, Elena Vital'evna Kirienkova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	type 2 diabetes insulin resistance adipokines bariatric surgery Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f3094fd87d024f07a41ca9787981870a
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spelling	oai:doaj.org-article:f3094fd87d024f07a41ca9787981870a2021-11-14T09:00:19ZAdipokines in metabolic processes regulating during obesity treatment2072-03512072-037810.14341/DM2014351-59https://doaj.org/article/f3094fd87d024f07a41ca9787981870a2014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6312https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Bariatric surgery serves as a model for the assessment of the relationship between body mass index (BMI) reduction and changes in adipokine production and for exploring the endocrine function of the pancreas in patients who do not have the proximal part of the small intestine. Aim. of the study was to assess the biochemical parameters and plasma levels of adipokines [adiponectin, adipsin, leptin, plasminogen activator inhibitor (PAI-1), resistin and visfatin], insulin, C-peptide, ghrelin and incretins [glucose insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)] in patients with morbid obesity after surgery (gastric bypass) and therapeutic correction. Materials and methods. A total of 75 patients (34 men and 41 women; age range: 24?67 years) diagnosed as obese were divided into two groups according to the treatment they received. Biochemical analysis was performed to estimate carbohydrate and lipid metabolism rates and plasma levels of adipokines (adiponectin, adipsin, leptin, PAI-1, resistin, visfatin), insulin, C-peptide, ghrelin and incretins (GIP and GLP-1) using the flow fluorometry. Results. Surgical treatment of obesity resulted in a significant decrease in BMI (from 45.67?9.87 to 32.45?5.35 kg/m2, pLarisa Sergeevna LitvinovaMaria Alexandrovna VasilenkoPavel Anatol'evich ZatolokinNatalya Nikolaevna AksenovaNikolay Sergeevich FattakhovIgor Zinov'evich VaysbeynNatalya Ivanovna MironyukElena Vital'evna KirienkovaEndocrinology Research Centrearticletype 2 diabetesinsulin resistanceadipokinesbariatric surgeryNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 51-59 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes insulin resistance adipokines bariatric surgery Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes insulin resistance adipokines bariatric surgery Nutritional diseases. Deficiency diseases RC620-627 Larisa Sergeevna Litvinova Maria Alexandrovna Vasilenko Pavel Anatol'evich Zatolokin Natalya Nikolaevna Aksenova Nikolay Sergeevich Fattakhov Igor Zinov'evich Vaysbeyn Natalya Ivanovna Mironyuk Elena Vital'evna Kirienkova Adipokines in metabolic processes regulating during obesity treatment
description	Bariatric surgery serves as a model for the assessment of the relationship between body mass index (BMI) reduction and changes in adipokine production and for exploring the endocrine function of the pancreas in patients who do not have the proximal part of the small intestine. Aim. of the study was to assess the biochemical parameters and plasma levels of adipokines [adiponectin, adipsin, leptin, plasminogen activator inhibitor (PAI-1), resistin and visfatin], insulin, C-peptide, ghrelin and incretins [glucose insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)] in patients with morbid obesity after surgery (gastric bypass) and therapeutic correction. Materials and methods. A total of 75 patients (34 men and 41 women; age range: 24?67 years) diagnosed as obese were divided into two groups according to the treatment they received. Biochemical analysis was performed to estimate carbohydrate and lipid metabolism rates and plasma levels of adipokines (adiponectin, adipsin, leptin, PAI-1, resistin, visfatin), insulin, C-peptide, ghrelin and incretins (GIP and GLP-1) using the flow fluorometry. Results. Surgical treatment of obesity resulted in a significant decrease in BMI (from 45.67?9.87 to 32.45?5.35 kg/m2, p
format	article
author	Larisa Sergeevna Litvinova Maria Alexandrovna Vasilenko Pavel Anatol'evich Zatolokin Natalya Nikolaevna Aksenova Nikolay Sergeevich Fattakhov Igor Zinov'evich Vaysbeyn Natalya Ivanovna Mironyuk Elena Vital'evna Kirienkova
author_facet	Larisa Sergeevna Litvinova Maria Alexandrovna Vasilenko Pavel Anatol'evich Zatolokin Natalya Nikolaevna Aksenova Nikolay Sergeevich Fattakhov Igor Zinov'evich Vaysbeyn Natalya Ivanovna Mironyuk Elena Vital'evna Kirienkova
author_sort	Larisa Sergeevna Litvinova
title	Adipokines in metabolic processes regulating during obesity treatment
title_short	Adipokines in metabolic processes regulating during obesity treatment
title_full	Adipokines in metabolic processes regulating during obesity treatment
title_fullStr	Adipokines in metabolic processes regulating during obesity treatment
title_full_unstemmed	Adipokines in metabolic processes regulating during obesity treatment
title_sort	adipokines in metabolic processes regulating during obesity treatment
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/f3094fd87d024f07a41ca9787981870a
work_keys_str_mv	AT larisasergeevnalitvinova adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT mariaalexandrovnavasilenko adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT pavelanatolevichzatolokin adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT natalyanikolaevnaaksenova adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT nikolaysergeevichfattakhov adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT igorzinovevichvaysbeyn adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT natalyaivanovnamironyuk adipokinesinmetabolicprocessesregulatingduringobesitytreatment AT elenavitalevnakirienkova adipokinesinmetabolicprocessesregulatingduringobesitytreatment
_version_	1718429564706750464

Adipokines in metabolic processes regulating during obesity treatment

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