Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities

Endometriosis is a common gynecological disease characterized by chronic inflammation, with an estimated prevalence of approximately 5–15% in reproductive-aged women. This study aimed to assess the relationship between placenta previa (PP) and endometriosis. We performed a systematic review of the l...

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Autores principales:	Shinya Matsuzaki, Yoshikazu Nagase, Yutaka Ueda, Mamoru Kakuda, Michihide Maeda, Satoko Matsuzaki, Shoji Kamiura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	placenta previa endometriosis pelvic adhesion cesarean delivery systematic review Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f30b51eaf10048a39ced08195bbffe32
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spelling	oai:doaj.org-article:f30b51eaf10048a39ced08195bbffe322021-11-25T16:48:44ZPlacenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities10.3390/biomedicines91115362227-9059https://doaj.org/article/f30b51eaf10048a39ced08195bbffe322021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1536https://doaj.org/toc/2227-9059Endometriosis is a common gynecological disease characterized by chronic inflammation, with an estimated prevalence of approximately 5–15% in reproductive-aged women. This study aimed to assess the relationship between placenta previa (PP) and endometriosis. We performed a systematic review of the literature until 30 June 2021, and 24 studies met the inclusion criteria. Using an adjusted pooled analysis, we found that women with endometriosis had a significantly increased rate of PP (adjusted odds ratio (OR) 3.17, 95% confidence interval (CI) 2.58–3.89) compared to those without endometriosis. In an unadjusted analysis, severe endometriosis was associated with an increased prevalence of PP (OR 11.86, 95% CI 4.32–32.57), whereas non-severe endometriosis was not (OR 2.16, 95% CI 0.95–4.89). Notably, one study showed that PP with endometriosis was associated with increased intraoperative bleeding (1.515 mL versus 870 mL, <i>p</i> < 0.01) compared to those without endometriosis. Unfortunately, no studies assessed the molecular mechanisms underlying PP in patients with endometriosis. Our findings suggest that there is a strong association between endometriosis and a higher incidence of PP, as well as poor surgical outcomes during cesarean delivery. Therefore, the development of novel therapeutic agents or methods is warranted to prevent PP in women with endometriosis.Shinya MatsuzakiYoshikazu NagaseYutaka UedaMamoru KakudaMichihide MaedaSatoko MatsuzakiShoji KamiuraMDPI AGarticleplacenta previaendometriosispelvic adhesioncesarean deliverysystematic reviewBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1536, p 1536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	placenta previa endometriosis pelvic adhesion cesarean delivery systematic review Biology (General) QH301-705.5
spellingShingle	placenta previa endometriosis pelvic adhesion cesarean delivery systematic review Biology (General) QH301-705.5 Shinya Matsuzaki Yoshikazu Nagase Yutaka Ueda Mamoru Kakuda Michihide Maeda Satoko Matsuzaki Shoji Kamiura Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
description	Endometriosis is a common gynecological disease characterized by chronic inflammation, with an estimated prevalence of approximately 5–15% in reproductive-aged women. This study aimed to assess the relationship between placenta previa (PP) and endometriosis. We performed a systematic review of the literature until 30 June 2021, and 24 studies met the inclusion criteria. Using an adjusted pooled analysis, we found that women with endometriosis had a significantly increased rate of PP (adjusted odds ratio (OR) 3.17, 95% confidence interval (CI) 2.58–3.89) compared to those without endometriosis. In an unadjusted analysis, severe endometriosis was associated with an increased prevalence of PP (OR 11.86, 95% CI 4.32–32.57), whereas non-severe endometriosis was not (OR 2.16, 95% CI 0.95–4.89). Notably, one study showed that PP with endometriosis was associated with increased intraoperative bleeding (1.515 mL versus 870 mL, <i>p</i> < 0.01) compared to those without endometriosis. Unfortunately, no studies assessed the molecular mechanisms underlying PP in patients with endometriosis. Our findings suggest that there is a strong association between endometriosis and a higher incidence of PP, as well as poor surgical outcomes during cesarean delivery. Therefore, the development of novel therapeutic agents or methods is warranted to prevent PP in women with endometriosis.
format	article
author	Shinya Matsuzaki Yoshikazu Nagase Yutaka Ueda Mamoru Kakuda Michihide Maeda Satoko Matsuzaki Shoji Kamiura
author_facet	Shinya Matsuzaki Yoshikazu Nagase Yutaka Ueda Mamoru Kakuda Michihide Maeda Satoko Matsuzaki Shoji Kamiura
author_sort	Shinya Matsuzaki
title	Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
title_short	Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
title_full	Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
title_fullStr	Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
title_full_unstemmed	Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities
title_sort	placenta previa complicated with endometriosis: contemporary clinical management, molecular mechanisms, and future research opportunities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f30b51eaf10048a39ced08195bbffe32
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Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities

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