Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells

Abstract Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidas...

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Autores principales:	Ravi Chauhan, Ajaz A. Bhat, Tariq Masoodi, Puneet Bagga, Ravinder Reddy, Ashna Gupta, Zahoor Ahmad Sheikh, Muzafar A. Macha, Mohammad Haris, Mayank Singh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ubiquitin Deubiquitylating enzymes Ubiquitin-specific peptidase Ubiquitin-specific peptidase 37 Oncogene Epithelial–mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f30bb74bc0b84bc2afa16a22ef8d081e
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spelling	oai:doaj.org-article:f30bb74bc0b84bc2afa16a22ef8d081e2021-11-14T12:15:23ZUbiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells10.1186/s13046-021-02163-71756-9966https://doaj.org/article/f30bb74bc0b84bc2afa16a22ef8d081e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13046-021-02163-7https://doaj.org/toc/1756-9966Abstract Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidases are attractive therapeutic targets in different cancers and are being evaluated for clinical development. Ubiquitin-specific peptidase 37 (USP37) is one of the least studied members of the USP family. USP37 controls numerous aspects of oncogenesis, including stabilizing many different oncoproteins. Recent work highlights the role of USP37 in stimulating the epithelial-mesenchymal transition and metastasis in lung and breast cancer by stabilizing SNAI1 and stimulating the sonic hedgehog pathway, respectively. Several aspects of USP37 biology in cancer cells are yet unclear and are an active area of research. This review emphasizes the importance of USP37 in cancer and how identifying its molecular targets and signalling networks in various cancer types can help advance cancer therapeutics.Ravi ChauhanAjaz A. BhatTariq MasoodiPuneet BaggaRavinder ReddyAshna GuptaZahoor Ahmad SheikhMuzafar A. MachaMohammad HarisMayank SinghBMCarticleUbiquitinDeubiquitylating enzymesUbiquitin-specific peptidaseUbiquitin-specific peptidase 37OncogeneEpithelial–mesenchymal transitionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ubiquitin Deubiquitylating enzymes Ubiquitin-specific peptidase Ubiquitin-specific peptidase 37 Oncogene Epithelial–mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Ubiquitin Deubiquitylating enzymes Ubiquitin-specific peptidase Ubiquitin-specific peptidase 37 Oncogene Epithelial–mesenchymal transition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ravi Chauhan Ajaz A. Bhat Tariq Masoodi Puneet Bagga Ravinder Reddy Ashna Gupta Zahoor Ahmad Sheikh Muzafar A. Macha Mohammad Haris Mayank Singh Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
description	Abstract Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to tumorigenesis. Ubiquitin-specific peptidases are attractive therapeutic targets in different cancers and are being evaluated for clinical development. Ubiquitin-specific peptidase 37 (USP37) is one of the least studied members of the USP family. USP37 controls numerous aspects of oncogenesis, including stabilizing many different oncoproteins. Recent work highlights the role of USP37 in stimulating the epithelial-mesenchymal transition and metastasis in lung and breast cancer by stabilizing SNAI1 and stimulating the sonic hedgehog pathway, respectively. Several aspects of USP37 biology in cancer cells are yet unclear and are an active area of research. This review emphasizes the importance of USP37 in cancer and how identifying its molecular targets and signalling networks in various cancer types can help advance cancer therapeutics.
format	article
author	Ravi Chauhan Ajaz A. Bhat Tariq Masoodi Puneet Bagga Ravinder Reddy Ashna Gupta Zahoor Ahmad Sheikh Muzafar A. Macha Mohammad Haris Mayank Singh
author_facet	Ravi Chauhan Ajaz A. Bhat Tariq Masoodi Puneet Bagga Ravinder Reddy Ashna Gupta Zahoor Ahmad Sheikh Muzafar A. Macha Mohammad Haris Mayank Singh
author_sort	Ravi Chauhan
title	Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
title_short	Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
title_full	Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
title_fullStr	Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
title_full_unstemmed	Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
title_sort	ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f30bb74bc0b84bc2afa16a22ef8d081e
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Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells

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