Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study

Objective: Microvascular invasion is considered to initiate intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to analyze the effect of MVI on the prognosis in HCC and identify related risk factors for microvascular invasion (MVI).Methods: The clinical d...

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Autores principales:	Wang Yanhan, Lu Lianfang, Liu Hao, Ding Yunfeng, Song Nannan, Lin Fanfan, Zhu Chengzhan, Wu Meilong, Sun Chuandong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatocellular carcinoma microvascular invasion prognosis risk factors recurrence Surgery RD1-811
Acceso en línea:	https://doaj.org/article/f310f6eea61a4e8190d8be3d614c0c98
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spelling	oai:doaj.org-article:f310f6eea61a4e8190d8be3d614c0c982021-11-17T04:38:05ZEffect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study2296-875X10.3389/fsurg.2021.733343https://doaj.org/article/f310f6eea61a4e8190d8be3d614c0c982021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.733343/fullhttps://doaj.org/toc/2296-875XObjective: Microvascular invasion is considered to initiate intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to analyze the effect of MVI on the prognosis in HCC and identify related risk factors for microvascular invasion (MVI).Methods: The clinical data of 553 HCC patients who underwent liver surgery at Qingdao University from January 2014 to December 2018 and 89 patients at Beijing Tsinghua Changgung Hospital treated between October 2014 and October 2019 were collected retrospectively. We explored the impact of MVI on the prognosis of patients with HCC using Kaplan-Meier analysis. We conducted logistic regression analysis to identify variables significantly related to MVI.Results: Pathological examination confirmed the presence of MVI in 265 patients (41.3%). Six factors independently correlated with MVI were incorporated into the multivariate logistic regression analysis: Edmondson-Steiner grade [odds ratio (OR) = 3.244, 95%CI: 2.243–4.692; p < 0.001], liver capsule invasion (OR = 1.755; 95%CI: 1.215–2.535; p = 0.003), bile duct tumor thrombi (OR = 20.926; 95%CI: 2.552–171.553; p = 0.005), α-fetoprotein (> 400 vs. < 400 ng/ml; OR = 1.530; 95%CI: 1.017–2.303; p = 0.041), tumor size (OR = 1.095; 95%CI: 1.027–1.166; p = 0.005), and neutrophil-lymphocyte ratio (OR = 1.086; 95%CI: 1.016–1.162; p = 0.015). The area under the receiver operating characteristic curve (AUC) was 0.743 (95%CI: 0.704–0.781; p < 0.001), indicating that our logistic regression model had significant clinical usefulness.Conclusions: We analyzed the effect of MVI on the prognosis in HCC and evaluated the risk factors for MVI, which could be helpful in making decisions regarding patients with a high risk of recurrence.Wang YanhanLu LianfangLiu HaoDing YunfengSong NannanLin FanfanZhu ChengzhanZhu ChengzhanWu MeilongSun ChuandongFrontiers Media S.A.articlehepatocellular carcinomamicrovascular invasionprognosisrisk factorsrecurrenceSurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma microvascular invasion prognosis risk factors recurrence Surgery RD1-811
spellingShingle	hepatocellular carcinoma microvascular invasion prognosis risk factors recurrence Surgery RD1-811 Wang Yanhan Lu Lianfang Liu Hao Ding Yunfeng Song Nannan Lin Fanfan Zhu Chengzhan Zhu Chengzhan Wu Meilong Sun Chuandong Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
description	Objective: Microvascular invasion is considered to initiate intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to analyze the effect of MVI on the prognosis in HCC and identify related risk factors for microvascular invasion (MVI).Methods: The clinical data of 553 HCC patients who underwent liver surgery at Qingdao University from January 2014 to December 2018 and 89 patients at Beijing Tsinghua Changgung Hospital treated between October 2014 and October 2019 were collected retrospectively. We explored the impact of MVI on the prognosis of patients with HCC using Kaplan-Meier analysis. We conducted logistic regression analysis to identify variables significantly related to MVI.Results: Pathological examination confirmed the presence of MVI in 265 patients (41.3%). Six factors independently correlated with MVI were incorporated into the multivariate logistic regression analysis: Edmondson-Steiner grade [odds ratio (OR) = 3.244, 95%CI: 2.243–4.692; p < 0.001], liver capsule invasion (OR = 1.755; 95%CI: 1.215–2.535; p = 0.003), bile duct tumor thrombi (OR = 20.926; 95%CI: 2.552–171.553; p = 0.005), α-fetoprotein (> 400 vs. < 400 ng/ml; OR = 1.530; 95%CI: 1.017–2.303; p = 0.041), tumor size (OR = 1.095; 95%CI: 1.027–1.166; p = 0.005), and neutrophil-lymphocyte ratio (OR = 1.086; 95%CI: 1.016–1.162; p = 0.015). The area under the receiver operating characteristic curve (AUC) was 0.743 (95%CI: 0.704–0.781; p < 0.001), indicating that our logistic regression model had significant clinical usefulness.Conclusions: We analyzed the effect of MVI on the prognosis in HCC and evaluated the risk factors for MVI, which could be helpful in making decisions regarding patients with a high risk of recurrence.
format	article
author	Wang Yanhan Lu Lianfang Liu Hao Ding Yunfeng Song Nannan Lin Fanfan Zhu Chengzhan Zhu Chengzhan Wu Meilong Sun Chuandong
author_facet	Wang Yanhan Lu Lianfang Liu Hao Ding Yunfeng Song Nannan Lin Fanfan Zhu Chengzhan Zhu Chengzhan Wu Meilong Sun Chuandong
author_sort	Wang Yanhan
title	Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
title_short	Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
title_full	Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
title_fullStr	Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
title_full_unstemmed	Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study
title_sort	effect of microvascular invasion on the prognosis in hepatocellular carcinoma and analysis of related risk factors: a two-center study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f310f6eea61a4e8190d8be3d614c0c98
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Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study

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