Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing

SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity for RNA and made it active on SMN2 exon7 splicing...

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Autores principales:	Antoine Cléry, Miroslav Krepl, Cristina K. X. Nguyen, Ahmed Moursy, Hadi Jorjani, Maria Katsantoni, Michal Okoniewski, Nitish Mittal, Mihaela Zavolan, Jiri Sponer, Frédéric H.-T. Allain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3116688ba6245dbbc7d39591d69df23
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spelling	oai:doaj.org-article:f3116688ba6245dbbc7d39591d69df232021-12-02T13:51:03ZStructure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing10.1038/s41467-020-20481-w2041-1723https://doaj.org/article/f3116688ba6245dbbc7d39591d69df232021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20481-whttps://doaj.org/toc/2041-1723SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity for RNA and made it active on SMN2 exon7 splicing.Antoine CléryMiroslav KreplCristina K. X. NguyenAhmed MoursyHadi JorjaniMaria KatsantoniMichal OkoniewskiNitish MittalMihaela ZavolanJiri SponerFrédéric H.-T. AllainNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoine Cléry Miroslav Krepl Cristina K. X. Nguyen Ahmed Moursy Hadi Jorjani Maria Katsantoni Michal Okoniewski Nitish Mittal Mihaela Zavolan Jiri Sponer Frédéric H.-T. Allain Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
description	SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity for RNA and made it active on SMN2 exon7 splicing.
format	article
author	Antoine Cléry Miroslav Krepl Cristina K. X. Nguyen Ahmed Moursy Hadi Jorjani Maria Katsantoni Michal Okoniewski Nitish Mittal Mihaela Zavolan Jiri Sponer Frédéric H.-T. Allain
author_facet	Antoine Cléry Miroslav Krepl Cristina K. X. Nguyen Ahmed Moursy Hadi Jorjani Maria Katsantoni Michal Okoniewski Nitish Mittal Mihaela Zavolan Jiri Sponer Frédéric H.-T. Allain
author_sort	Antoine Cléry
title	Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
title_short	Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
title_full	Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
title_fullStr	Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
title_full_unstemmed	Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing
title_sort	structure of srsf1 rrm1 bound to rna reveals an unexpected bimodal mode of interaction and explains its involvement in smn1 exon7 splicing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3116688ba6245dbbc7d39591d69df23
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Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing

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